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Table 3 Dose cutpoint, sensitivity, specificity and positive likelihood ratio, positive predictive value (PPV), negative predictive value (NPV) and relative risk (RR)

From: Dose-volume relationship for laryngeal substructures and aspiration in patients with locally advanced head-and-neck cancer

 

Mean dose cutpoint (cGy)

Number (%) of aspirators above cutpoint (sensitivity)

Number (%) of non-aspirators below cutpoint (specificity)

Positive likelihood ratio: sensitivity/(100-specificity)

PPV(%)a

NPV(%)b

RRc

Structure

 AE Folds

6500

9/10 (90.0)

13/19 (68.4)

2.81

60.0

92.9

8.4

 Arytenoids

6000

8/10 (80.0)

14/19 (73.7)

3.04

61.5

87.5

4.9

 Glossoepiglottic fold

7000

10/10 (100.0)

8/19 (42.1)

1.73

47.6

100.0

undefined

 Cricoid cartilage

6000

7/10 (70.0)

14/19 (73.7)

2.66

58.3

82.4

3.3

 Thyroid cartilage

6450

9/10 (90.0)

14/19 (73.7)

3.42

64.3

93.3

9.6

 Epiglottis

7225

7/10 (70.0)

14/19 (73.7)

2.66

58.3

82.3

3.3

 Suprahyoid epiglottis

6810

10/10 (100.0)

9/19 (47.4)

1.90

50.0

100.0

undefined

 Infrahyoid epiglottis

6300

9/10 (90.0)

12/19 (63.2)

2.45

56.3

92.3

7.3

 Total larynx

6100

9/10 (90.0)

13/19 (68.4)

2.85

60.0

92.9

8.5

 Supraglottic larynx

6650

9/10 (90.0)

13/19 (68.4)

2.85

60.0

92.9

8.5

 Subglottic larynx

5750

7/10 (70.0)

13/19 (68.4)

2.66

53.9

81.3

2.9

 Glottic larynx

6100

8/10 (80.0)

14/19 (73.7)

2.81

61.5

87.5

4.9

  1. aPPV should be greater than the a priori prevalence of aspiration which is 34.5%
  2. bNPV should be greater than the a priori prevalence of no aspiration which is 65.5%
  3. cRR is undefined if denominator is zero