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Table 5 The previous studies reporting severe RP after radiotherapy in patients with IPF

From: Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy

  Number of Patients Median follow-up (month, range) Treatment Median total dose Grade ≥ 4 RP
Yamashita et al. 13 14.7 (0.3–76.2) SBRT 48.0 Gy 7 (53.8%)
Lee et al. 14 15.5 (6.1–40.9) 3DCRT 56.9 Gy 5 (35.7%)
Yamaguchi et al. 16 SBRT 48.0 Gy 2 (12.5%)
Ono et al. 16 12.0 (4–39) PBT 80.0 Gy (RBE) 1 (6.3%)
Current study 30 11.0 (2–51) X-raya/PBT 60.0 Gy 18.2% (4/22) in X-ray 0% (0/8) in PBT
  1. RP radiation pneumonitis, IPF idiopathic pulmonary fibrosis, SBRT stereotactic body radiation therapy, 3DCRT 3-dimensional conformal radiation therapy, PBT proton beam therapy
  2. aX-ray treatment includes 3DCRT, SBRT, and intensity-modulated radiation therapy (IMRT)