Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy

Table 5 The previous studies reporting severe RP after radiotherapy in patients with IPF

	Number of Patients	Median follow-up (month, range)	Treatment	Median total dose	Grade ≥ 4 RP
Yamashita et al.	13	14.7 (0.3–76.2)	SBRT	48.0 Gy	7 (53.8%)
Lee et al.	14	15.5 (6.1–40.9)	3DCRT	56.9 Gy	5 (35.7%)
Yamaguchi et al.	16	–	SBRT	48.0 Gy	2 (12.5%)
Ono et al.	16	12.0 (4–39)	PBT	80.0 Gy (RBE)	1 (6.3%)
Current study	30	11.0 (2–51)	X-ray^a/PBT	60.0 Gy	18.2% (4/22) in X-ray 0% (0/8) in PBT

RP radiation pneumonitis, IPF idiopathic pulmonary fibrosis, SBRT stereotactic body radiation therapy, 3DCRT 3-dimensional conformal radiation therapy, PBT proton beam therapy
^aX-ray treatment includes 3DCRT, SBRT, and intensity-modulated radiation therapy (IMRT)