Table 1 Baseline and clinical characteristics of patients and their correlation with grade ≥ 2 acute radiation pneumonitis
Characteristics | No. of Patients (N = 183) (%) | No. of Grade ≥ 2 RP (N = 26) (%) | Odds Ratio | 95% CI | P Value* |
|---|---|---|---|---|---|
Age | |||||
≤ 63 (Median) | 98 (53.6) | 13(50.0) | Reference | ||
> 63 (Median) | 84(45.9) | 13(50.0) | 1.21 | 0.53–2.78 | 0.651 |
Gender | |||||
Male | 162(88.5) | 20(76.9) | Reference | ||
Female | 21(11.5) | 6(23.1) | 2.84 | 0.99–8.17 | 0.053 |
Smoking | |||||
Never | 42(23.0) | 7(26.9) | Reference | 0.644 | |
Current | 77(42.1) | 12(46.2) | 0.92 | 0.33–2.56 | 0.878 |
Former | 64(35.0) | 7 (26.9) | 0.61 | 0.20–1.90 | 0.397 |
Pathology | |||||
Squamous | 112(61.7) | 19 (73.1) | Reference | 0.570 | |
Adenocarcinoma | 30(16.4) | 3(11.5) | 0.54 | 0.15–1.98 | 0.355 |
Small Cell | 35(19.7) | 3(11.5) | 0.46 | 0.13–1.65 | 0.234 |
Others | 6(2.2) | 1(3.8) | 0.98 | 0.11–8.86 | 0.985 |
Stage | |||||
I/II | 14(7.7) | 0(0) | 0.00 | 0.999 | |
III | 115(62.8) | 20 (76.9) | Reference | 0.578 | |
IV | 54(29.5) | 6 (23.1) | 0.59 | 0.22–1.58 | 0.295 |
Chemo | |||||
No | 25(13.7) | 1(3.8) | Reference | ||
Yes | 158(86.3) | 25(96.2) | 4.51 | 0.58–34.89 | 0.149 |
Surgery | |||||
No | 139(76) | 20(76.9) | Reference | ||
Yes | 44(24) | 6(23.1) | 0.94 | 0.35–2.51 | 0.901 |
PGTV Volume | |||||
≤ 135.1 (Median) | 92(50) | 13(50) | Reference | ||
> 135.1 (Median) | 91(50) | 13(50) | 1.0 | 0.44–2.32 | 0.976 |
PTV Volume | |||||
≤ 543.6 (Median) | 92(50) | 17(65) | Reference | ||
> 543.6 (Median) | 91(50) | 9(35) | 0.48 | 0.20–1.15 | 0.101 |
PGTV prescription | |||||
≤ 54 (Median) | 113(62) | 14(54) | Reference | ||
> 54 (Median) | 70(38) | 12(46) | 1.46 | 0.63–3.38 | 0.373 |
PTV prescription | |||||
≤ 50 (Median) | 161(88) | 23(88) | Reference | ||
> 50 (Median) | 22(12) | 3(12) | 0.95 | 0.26–3.46 | 0.935 |