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Table 1 Patient, tumor and treatment characteristics

From: Progression of hearing loss after LINAC-based stereotactic radiotherapy for vestibular schwannoma is associated with cochlear dose, not with pre-treatment hearing level

 

SRS group (67 patients)

FSRT group (27 patients)

ANOVA

p-value

N (%)

mean/ median

range

N (%)

mean/ median

range

Patients

 Age

67

58/59

34–80

27

48/51

27–79

< 0.001

Gender

0.2

 Male

32

  

9

   

 Female

35

  

18

   

Hearing

 GR baseline class

0.01

 1

7 (10,4)

  

13 (48.1)

   

 2

30 (44.8)

  

7 (25.9)

   

 3

28 (41.8)

  

5 (18.5)

   

 4

2 (2.9)

  

2 (7.4)

   

 Δ PTA (dB/month)

 

1.35/0.95

−0.86-11.13

 

2.9/1.65

−0.65-28

0.05

 PTA pre-treatment (dB)

 

48.2/46.3

1.3–96

 

36/34

3.7–94

0.02

 SDS pre-treatment (%)

 

78/85

18–100

 

83/94

3–100

0.38

Tumors

 Tumor side

  Left

37

  

14

  

0.8

  Right

30

  

13

   

 Tumor volume Pre-treatment (ml)

 

3.0/2.36

0.37–12.82

 

7.4/6.8

0.24–20.1

0.003

 Tumor diameter CPA (cm)

 

1.7/1.56

0.64/3.34

 

2.4/2.56

0.67/4.22

< 0.001

 Tumor diameter IAC (cm)

 

0.88/0.93

0.15/1.39

 

0.83/0.93

0/1.41

0.453

Radiation

 Cochlear volume (ml)

 

0.17/0.17

0.08–0.31

 

0.22/0.22

0.17–0.36

< 0.001

 Max cochlear dose EQD2

 

3578/3990

448–6693

 

4623/4840

3428–5258

< 0.001

 Mean cochlear dose EQD2

 

1054/736

114–3211

 

3569/3781

1355–4866

< 0.001

 V90 EQD2 (mm3)

 

4/0

0–51

 

65/50

0–256

< 0.001

 Follow-up time (months)

 

37/36

4.8–121

 

61/63

8.3–123

< 0.001

  1. All radiation doses are given in Gy in EQD2