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Table 1 Inclusion criteria

From: Phase II trial on SBRT for unresectable liver metastases: long-term outcome and prognostic factors of survival after 5 years of follow-up

Inclusion criteria
 • Liver metastases considered not suitable for surgery, because of being technically or medically inoperable or because of patient refusal;
 • Maximum tumor diameter less than 6 cm;
 • No more than 3 liver lesions;
 • Normal liver volume greater than 1000 cm3;
 • No evidence of progressive or untreated gross disease outside of the liver;
 • No prior radiation therapy to the targeted area;
 • Adequate liver function, defined as total bilirubin < 3 mg/dL, albumin > 2.5 g/dL, normal prothrombin time (PT)/partial thromboplastin time (PTT) unless on anticoagulants, and serum levels of aspartate aminotransferase (AST) and alanine amynotransferase (ALT) less than 3 times the upper limit of normal;
 • No concurrent chemotherapy allowed, either within 14 days before SBRT or until the first revaluation thereafter;
 • No active connective tissue disorders;
 • Karnofsky Performance Status 70;
 • Minimum age 18 years;
 • Written informed consent.