Table 3 Published studies of Pre-op SRS prior to Metastases Resection
Study | Treatment Modalities (Number of patients) | Target | Median survival (months) | Outcomes | |||
|---|---|---|---|---|---|---|---|
LR (%) | DBF (%) | LMD (%) | Symptomatic RN (%) | ||||
Asher, 2014 [28] | PreOP SRS (47) | GTV = PTV | NA | 14.4 (1 yr) | 38.2 (1 yr) | NA | NA |
Patel, 2016 [29] | PreOP SRS (66) Vs. Postop SRS (114) | GTV = PTV PTV = cavity + 1–2 mm margin | 17.1 13.5 | 15.9 (1 yr) 12.6 (1 yr) | 32 (1 yr) 39.1(1 yr) | 3.2 (1 yr) 3.2 (2 yr) 8.3 (1 yr) 16.6 (2 yr) | 4.9 (2 yr) 16.4 (2 yr) |
Patel, 2017 [44] | PreOP SRS (66) Vs. Postop WBRT [36] | GTV = PTV PTV = cavity + 1–2 mm margin | 13.9 12.6 | 24.5 (2 yr) 25.1 (2 yr) | 53.2 (2 yr) 45 (2 yr) | 3.5 (2 yr) 9 (2 yr) | 5.6 (2 yr) 0 (2 yr) |
Prabhu, 2018 (Abstract only) | Pre-OP SRS (117) | GTV = PTV | 17.2 | 19.9 (1 yr); 25.1 (2 yr) | 45.3 (1 yr); 60.2 (2 yr) | 4.3 (1 yr); 4.3 (2 yr) | 2.6 (1 yr) 4.8 (2 yr) |