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Table 2 Summary of average ± s.d. doses to PTVs and OAR for the 20 patients in Set_2

From: Effectiveness of Multi-Criteria Optimization-based Trade-Off exploration in combination with RapidPlan for head & neck radiotherapy planning

Structure Parameter a - Clinical b - Clinical + TO c - RP_1 d - RP_1 + TO e - RP_TO f - RP_ TO+
PTV 1 D99% > 90%
p < 0.05
93.7 ± 0.9
c
94.1 ± 2.0 94.2 ± 1.2
a,e
93.8 ± 2.5 93.6 ± 1.5
c
93.7 ± 2.3
D95% > 95%
p < 0.05
96.1 ± 0.6
b,c,d
96.8 ± 0.8
a,c,e,f
96.3 ± 0.7
a,b,e
96.6 ± 1.0
a,e
96.0 ± 0.9
b,c,d,f
96.4 ± 0.9
b,e
D5% < 105%
p < 0.05
102.9 ± 0.5
b,d
102.4 ± 0.5
a,c,e,f
102.7 ± 0.4
b,d,e
102.4 ± 0.7
a,c,e,f
103.1 ± 0.6
b,c,d,
102.8 ± 0.8
b,d,
D2% < 107%
p < 0.05
103.5 ± 0.7
b,d,e
103.0 ± 0.8
a,c,e,f
103.4 ± 0.6
b,e
103.5 ± 0.9
a,e,f
103.8 ± 0.8
a,b,c,d
103.7 ± 1.2
b,d
HI
p < 0.05
1.07 ± 0.01
b,c,d
1.06 ± 0.01
a,c,e,f
1.07 ± 0.01
a,b,d,e
1.06 ± 0.02
a,e,f
1.07 ± 0.01
b,c,d,f
1.07 ± 0.02
b,d,e
PTV LR D99% > 74.8%
p < 0.05
77.4 ± 0.6
c,f
77.1 ± 1.0
c,f
78.4 ± 0.7
a,b,d,e,f
77.0 ± 1.4
c,f
77.5 ± 1.0
c,f
76.0 ± 1.2
a,b,c,d,e
D95% > 78.9%
p < 0.05
79.7 ± 0.4
b,c,d,f
81.1 ± 0.9
a,c,e
80.2 ± 0.5
a,b,d,e,f
81.2 ± 0.6
a,c,e
79.9 ± 0.6
b,c,d,f
80.8 ± 0.9
a,c,e
HI
p < 0.05
1.13 ± 0.02
b,c,d,f
1.16 ± 0.02
a,c,e,f
1.12 ± 0.01
a,b,d,e,f
1.16 ± 0.02
a,c,e,f
1.13 ± 0.01
b,c,d,f
1.17 ± 0.02
a,b,c,d,e
PRV Brainstem DMax < 48Gy
p < 0.05
26.9 ± 15.7
b,c,d,e,f
24.3 ± 14.5
a,f
25.9 ± 14.8
a,d,e,f
23.2 ± 13.3
a, c,
23.9 ± 13.5
a,c,f
20.9 ± 11.6
a,b,c,e
PRV Spinal Cord D1% < 44Gy
p < 0.05
37.6 ± 2.7
b,c,d,e,f
32.7 ± 2.9
a,c,d,f
36.4 ± 2.2
a,b,d,e,f
30.5 ± 3.1
a,b,c,f
31.5 ± 3.0
a,c,f
27.5 ± 4.7
a,b,c,d,e
DMax < 48Gy
p < 0.05
40.4 ± 2.9
b,d,e,f
35.1 ± 2.9
a,c,f
39.3 ± 2.2
b,d,e,f
33.6 ± 3.4
a,c,f
34.3 ± 3.5
a,c,f
30.8 ± 4.9
a,b,c,d,e
Left Parotid DMean < 24Gy
p < 0.05
22.9 ± 5.5
b,d,e,f
16.7 ± 4.8
a,c,f
22.3 ± 5.5
b,d,e,f
16.7 ± 4.5
a,c,f
16.8 ± 4.9
a,c,f
15.0 ± 4.6
a,b,c,d,e
Right Parotid DMean < 24Gy
p < 0.05
24.8 ± 5.8
b,d,e,f
19.1 ± 4.4
a,c,f
24.2 ± 5.4
b,d,e,f
18.4 ± 4.7
a,c,f
19.0 ± 5.9
a,c,f
17.1 ± 5.0
a,b,c,d,e
CI V100%/VPTVs
p < 0.05
0.27 ± 0.08
b,d,
0.29 ± 0.09
a,c,e
0.27 ± 0.08
b,d,f
0.29 ± 0.09
a,c
0.28 ± 0.09
b,
0.29 ± 0.09
c,
V80%/VPTVs
p < 0.05
1.26 ± 0.14
b,d,f
1.47 ± 0.15
a,c,d,e,f
1.23 ± 0.06
b,d,f
1.40 ± 0.08
a,b,c,e
1.24 ± 0.06
b,d,f
1.41 ± 0.07
a,b,c,e
V50%/VPTVs
p < 0.05
2.55 ± 0.33
b,d,f
2.94 ± 0.41
a,c,d,e,f
2.49 ± 0.19
b,d,e,f
2.79 ± 0.25
a,b,c,e
2.52 ± 0.21
b,c,d,f
2.84 ± 0.29
a,b,c,e
V10%/VPTVs
p < 0.05
9.31 ± 1.89
b,d,f
9.55 ± 1.90
a,c,d,e,f
9.28 ± 1.84
b,d,f
9.41 ± 1.81
a,b,c,e
9.28 ± 1.81
b,d,f
9.39 ± 1.78
a,b,c,e
Right Parotid DMean < 24Gy
p < 0.05
24.8 ± 5.8
b,d,e,f
19.1 ± 4.4
a,c,f
24.2 ± 5.4
b,d,e,f
18.4 ± 4.7
a,c,f
19.0 ± 5.9
a,c,f
17.1 ± 5.0
a,b,c,d,e
Total Fails Parameters 22 2 20 4 11 3
Plans 13 2 13 3 7 2
  1. Comparisons are based on the Wilcoxon signed-rank test and significant differences (p-value < 0.05) between planning methods are indicated with the letters. The last two rows show the number of plans in each group that failed to meet all the constraints and the number of parameters that were violated within them