Table 5 Summary of literature on toxicity and relative doses in salvage radiotherapy for locoregional recurrent NSCLC after surgery

Kagami et al., 1998 [20]

Retrospective

n.s.

AP-PA until 40 Gy, then opposite oblique technique

PTV: GTV (margins n.s.)

47.5–65

–

No G3

Uno et al., 2005 [21]

Retrospective

2–8 months

3D-CRT

PTV1: uninvolved mediastinal and ipsilateral hilar lymphnodes+ 10–15 mm

PTV2:GTV + 10 mm

60 (46–60)

wCBDCA (7)

wCBDCA-PTX (2)

wCBDCA-VDS (1)

wCBDCA-VNB (1)

wCDDP (1)

Pneumonitis G3 (4.7)

Hematologic G3 (4.7)

Hematologic G4 (4.7)

Kelsey et al., 2006 [22]

Retrospective

n.s.

n.s.

PTV: ENI (27/29; n.s. in others)

66 (46–74)

NAD to RT (7)

Concomitant (8)

Esophagitis + stenosis G3 (6.8)

Bae et al., 2012

Retrospective

32 months

3D-CRT

PTV: GTV + 10–20 mm

Median BED₁₀ 70.2 (51.5–85.8)

wCDDP-PTX (12)

CDDP-Eto q28 (2)

Pneumonitis G3 (9.4%)

Pneumonitis G4 (1.6%)

Bar et al., 2013 [18]

Retrospective

n.s.

3D-CRT (43)

n.s.

63.5 (26–66)

CDDP-VNL q21 (14)

wCBDCA-PTX (7)

CDDP-Eto q 21 (4)

Other platinum reg. (5)

Pneumonitis G3 (7)

Pneumonitis G4 (3.5)

Esophagitis G3 (14)

Febrile neutropenia (14)

Esophageal stenosis (7)

Other G3/4 (5/1): hearing loss (2), depression (1), neuropathy (1), nausea (1), pulmonary embolus (1)

Lee et al., 2013 [14]

Retrospective

26.4 months

3D-CRT

PTV: GTV + 10 mm for the CTV + 5–15 mm

Ipsilateral hilum usually included,

Median BED₁₀ 74.4 (58.5–97.5)

CDDP-Eto (9)

CBDCA-PTX (3)

Esophagitis G3 (2.6%)

Takenada et al., 2015

Retrospective

n.s.

n.s.

n.s.

60 (30–60)

CDDP-S1 (11)

CDDP-Tegafur-Uracil (8)

CBDCA-VNL (10)

Other CDDP reg. (4)

Other CBDCA reg. (2)

Esophagitis G3 (9)

Neutropenia G3 (14)

Neutropenia G4 (20)

Cardiac G3 (2)

Miscellaneous infection (9)

Other G3 (11)

Kim et al., 2017 [13]

Retrospective

53.6 months

3D-CRT

PTV: GTV + 5–8 mm for the CTV + 10 mm

Median BED₁₀ 79.2 (58.5–84)

wCDDP-PTX (40)

CDDP-Eto q21 (2)

Pneumonitis G3 (5.3)

Esophagitis G3 (3.5)

Nakamichi et al., 2017 [19]

Retrospective

n.s.

n.s.

Lung lesions+recurrent lymphnodes+regional nodes

Median 60 (50–70)

CDDP-VNL q28 (14)

CBDCA-PTX (3)

CDDP-PTX (1)

RT group (56):

Pneumonitis G3 (5)

Late pulm. Toxicity (2)

Other non-hematologic (2)

R-CT group (18):

Febrile neutropenia (17)

Pneumonitis G3 (5)

Esophagitis Ge (5)

Other non-hematologic (5)

Seol et al., 2017 [16]

Retrospective

14 months

3D-CRT

PTV: GTV + 10–20 mm + adjacent nodal areas (mediastinal and hilar) considered at risk+ 3–5 mm

66 (51–66)

NAD CT (7)

Concomitant CT (7)

NAD CT + R-CT (1)

RT + Adj CT (1)

Pneumonitis G3 (3.2)

Nicosia et al. (present study)

Retrospective

12 months

IMRT-SIB

PTV1: GTV + 5 mm

PTV2: involved nodal station + adjacent stations and hilum + 7 mm

50 + boost 62.5

wCDDP (9)

Pneumonitis G3 (7.1)