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Table 3 Radiation doses according to the change in cIBS

From: Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer

Structure ≥15% increase in cIBS (n = 29) < 15% increase in cIBS (n = 35)  
Md (IQR) Md (IQR) p
Heart
 Dmean (Gy) 3.4 (1.1–4.2) 1.6 (0.8–2.7) 0.011
 Dmax (Gy) 47.2 (15.0–48.8) 44.5 (6.4–47.1) 0.068
 V45 (%) 0.5 (0–1.7) 0 (0–0.4) 0.025
 V20 (%) 4.4 (0–6.2) 1.1 (0–2.4) 0.005
LAD
 Dmean (Gy) 22.9 (2.3–27.3) 7.3 (0.4–18.0) 0.042
 Dmax (Gy) 45.9 (5.3–46.8) 36.3 (0.6–45.3) 0.040
 V45 (%) 0.4 (0–13.9) 0 (0–0.3) 0.008
 V20 (%) 42.7 (0–68.7) 8.9 (0–38.4) 0.041
Left ventricle
 Dmean (Gy) 4.9 (1.2–7.0) 2.3 (0.2–3.8) 0.023
 Dmax (Gy) 45.8 (9.0–47.8) 41.7 (0.7–45.9) 0.080
 V45 (%) 0.1 (0–2.9) 0 (0–0.2) 0.006
 V20 (%) 6.7 (0–10.4) 1.3 (0–4.7) 0.021
 V10 (%) 9.0 (0–15.0) 3.0 (0–6.5) 0.006
Right ventricle (n = 49)
 Dmean (Gy) 2.4 (1.1–3.1) 1.5 (0.9–2.3) 0.074
 Dmax (Gy) 29.6 (3.6–44.0) 8.1 (3.0–39.3) 0.189
 V45 (%) 0 (0–0) 0 (0–0) 0.150
 V20 (%) 0.1 (0–2.7) 0 (0–0.4) 0.053
 V10 (%) 0.9 (0–6.5) 0 (0–1.4) 0.019
Lung
 Dmean (Gy) 8.2 (7.6–9.6) 6.8 (5.5–8.2) 0.001
 Dmax (Gy) 50.1 (47.9–56.7) 47.5 (46.4–49.7) 0.009
  1. Md median, IQR interquartile range, Dmean mean radiation dose to the structure, Dmax maximum radiation dose within the structure, V45 percentage of the structure volume receiving 45 Gy of radiation, V20 percentage of the structure volume receiving 20 Gy of radiation, V10 percentage of the structure volume receiving 10 Gy of radiation, LAD left anterior descending coronary artery