Organ | Criteria/endpoint | Original plan | Scenario 2 | Scenario 3 | Scenario 4 | Scenario 5 |
---|---|---|---|---|---|---|
Spinal chord | D2% < 42 [Gy] | 32.7 ± 3.8 | 32.9 ± 3.8 | 32.8 ± 3.8 | 34.0 ± 3.8 | 33.5 ± 3.8 |
23.3–41-3 | 23.4–41.5 | 23.3–41.5 | 24.1–42.6 | 23.7–42.1 | ||
Myelitis/Necrosis [%] | 0.1 ± 0.4 | 0.1 ± 0.4 | 0.1 ± 0.4 | 0.1 ± 0.5 | 0.1 ± 0.5 | |
0–2 | 0–2 | 0–2 | 0–2 | 0–2 | ||
Right Parotid gland | Mean < 25 [Gy] | 19.3 ± 4.6 | 19.5 ± 4.6 | 19.4 ± 4.6 | 20.6 ± 4.8 | 20.0 ± 4.7 |
9.5–25.4 | 9.6–25.5 | 9.6–25.6 | 10.7–27.3 | 10.2–26.5 | ||
V20Gy < 60 [%] | 35.0 ± 14.8 | 35.5 ± 15.1 | 35.3 ± 15.0 | 38.2 ± 16.4 | 36.7 ± 15.6 | |
0.0–57.9 | 0.0–59.3 | 0.0–58.3 | 0.0–63.0 | 0.0–60.9 | ||
Xerostomia [%] | 0.5 ± 0.8 | 0.5 ± 0.8 | 0.5 ± 0.8 | 0.8 ± 1.2 | 0.7 ± 1.0 | |
0–3 | 0–3 | 0–3 | 0–5 | 0–4 | ||
Left Parotid gland | Mean < 25 [Gy] | 20.7 ± 4.0 | 21.1 ± 4.0 | 20.9 ± 4.0 | 22.2 ± 4.2 | 21.6 ± 4.1 |
12.6–25.6 | 12.8–25.7 | 12.7–25.6 | 13.6–27.3 | 13.2–26.5 | ||
V20Gy < 60 [%] | 41.0 ± 11.2 | 41.7 ± 11.5 | 41.3 ± 11.3 | 44.5 ± 12.5 | 43.1 ± 11.9 | |
17.8–56.8 | 18.0–57.4 | 17.9–57.0 | 18.9–61.3 | 18.4–59.1 | ||
Xerostomia [%] | 0.6 ± 0.9 | 0.6 ± 0.9 | 0.6 ± 0.9 | 1.1 ± 1.3 | 0.8 ± 1.0 | |
0–3 | 0–3 | 0–3 | 0–5 | 0–4 | ||
Larynx | D2% < 63 [Gy] | 54.8 ± 5.2 | 55.2 ± 5.2 | 55.0 ± 5.2 | 56.5 ± 5.3 | 55.8 ± 5.2 |
43.8–63.4 | 44.1–63.8 | 43.9–63.5 | 45.5–65.1 | 44.7–64.3 | ||
Mean < 44 [Gy] | 34.4 ± 4.7 | 34.8 ± 4.7 | 34.5 ± 4.8 | 36.1 ± 4.8 | 35.4 ± 4.8 | |
18.2–42.9 | 19.4–43.3 | 18.3–43.0 | 19.5–44.8 | 19.0–43.9 | ||
Edema [%] | 11.2 ± 8.2 | 11.8 ± 8.5 | 11.4 ± 8.3 | 15.5 ± 10.3 | 12.7 ± 9.4 | |
0–30 | 0–32 | 0–31 | 0–37 | 0–34 | ||
Vocal chords | D2% < 25 [Gy] | 22.0 ± 2.2 | 22.3 ± 2.3 | 22.1 ± 2.2 | 23.7 ± 2.2 | 23.0 ± 2.2 |
17.5–26.0 | 17.7–26.3 | 17.6–26.1 | 20.0–27.8 | 18.8–26.9 |