Table 5 Association of treatment factors and treatment toxicity
Acute toxicity max grade (n = 37) | Late toxicity max grade (n = 32) | |||||||
|---|---|---|---|---|---|---|---|---|
0 | 1–2 | 3 | p-value | 0 | 2 | 4 | p-value | |
Number of fiducials† | ||||||||
0–1 | 1 | 6 | 0 | 0.0002* | 4 | 1 | 2 | 0.01* |
2–4 | 10 | 17 | 3 | 22 | 1 | 2 | ||
Treatment days † | ||||||||
3 | 11 | 20 | 3 | 0.37 | 25 | 2 | 2 | 0.012* |
4–7 | 0 | 3 | 0 | 1 | 0 | 2 | ||
Previous surgery† | ||||||||
Yes | 1 | 5 | 0 | 0.47 | 4 | 0 | 1 | 0.68 |
No | 10 | 18 | 3 | 22 | 2 | 3 | ||
Previous irradiation† | ||||||||
Yes | 0 | 7 | 1 | 0.11 | 6 | 0 | 0 | 0.43 |
No | 11 | 16 | 2 | 20 | 2 | 4 | ||
Min dose to PTV† | ||||||||
< 22.35Gy | 5 | 10 | 2 | 0.75 | 9 | 2 | 2 | 0.17 |
≥ 22.35Gy | 6 | 11 | 1 | 17 | 0 | 2 | ||
SABR purpose† | ||||||||
Sole primary | 1 | 6 | 0 | 0.064 | 6 | 1 | 0 | 0.62 |
Adjuvant | 6 | 4 | 1 | 7 | 0 | 1 | ||
Consolidation | 4 | 6 | 1 | 8 | 1 | 1 | ||
Retreat | 0 | 5 | 2 | 5 | 0 | 2 | ||
Treatment time (mins) | 77.5 | 69.9 | 68.3 | 0.570 | 67.7 | 59.5 | 83.0 | 0.045* |
PTV (cc) ‡ | 93.5 | 72.1 | 67.9 | 0.355 | 77.2 | 61.5 | 79.3 | 0.875 |
PTV min dose (cGy) ‡ | 2342.6 | 2227.6 | 2115.8 | 0.605 | 2317.7 | 1901.5 | 2332.4 | 0.396 |
PTV max dose (cGy) ‡ | 3951.3 | 3974.7 | 4149.2 | 0.8819 | 4120.6 | 3920.5 | 3861.9 | 0.622 |
PTV mean dose (cGy) ‡ | 3151.9 | 3118.0 | 3241.9 | 0.879 | 3225.4 | 3085.6 | 3015.0 | 0.493 |
Prescription dose (cGy) ‡ | 2736.4 | 2647.8 | 2700.0 | 0.735 | 2740.4 | 2700.0 | 2612.5 | 0.7067 |
Prescription isodose (%) ‡ | 69.6 | 67.5 | 65.3 | 0.554 | 67.0 | 69.0 | 68.3 | 0.882 |
Percentage cover (%) ‡ | 96.1 | 97.0 | 97.3 | 0.771 | 97.1 | 88.1 | 91.1 | 0.002* |
BED (Gy10) ‡ | 52.3 | 49.2 | 52.0 | 0.650 | 52.1 | 51.0 | 49.0 | 0.811 |
HI ‡ | 1.44 | 1.50 | 1.54 | 0.523 | 1.51 | 1.46 | 1.47 | 0.833 |