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Table 1 (Reported) Study Inclusion criteria and radiation schedules in the included trials. All Staging is defined by pathology

From: Accelerated vs. conventionally fractionated adjuvant radiotherapy in high-risk head and neck cancer: a meta-analysis

  Ang et al. 2001 [9] Awwad et al. 2002 [11] Langendijk et al. 2015 [7] Sanguineti et al. 2005 [8] Suwinski et al. 2008 [10] CHARTWEL unpublisheda
N patients 151 70 148 226 279 114
Median Follow-up (years; IQR) 13.8 (8.0–16.9) 3.8 (1.6–4.7) 6.3 (5.3–8.0) 4.5 (3.4–6.2) 7.2 (6.3–8-0) 4.8 (3.9–5.4)
Histology squamous cell carcinoma n.a.
Localisation oral cavity / oropharynx / hypopharynx / larynx oral cavity / hypopharynx / larynx n.a. oral cavity / oropharynx / hypopharynx / larynx oral cavity / oropharynx / larynx oral cavity / oropharynx / hypopharynx / larynx /other
ECOG PS ≤ 2 ≤ 2 n.a. ≤ 2 ≤ 1 ≤ 2
Age (years) n.a. ≤ 65 n.a. 18–80 n.a. n.a.
Resection planned surgical resection without macroscopic residual (R0/R1) n.a.
Definition of “High Risk” situation ECE or any two of following:
- > 1 nodal group
- ≥2 positive nodes
- > 3-cm node
- Oral cavity
- Microscopic pos. Margin
- Perineural invasion (Pn1)
- T2/N1–2
or
- T3–4/any N
- positive surgical margins
and/or
- extranodal spread (ECE)
one or more of following risk factors:
- pT4
- close margin (< 3 mm)
- V1
- L1
- pN2–3
- ECE
- time from surgery: ≤ 8 w
all non-laryngeal tumors (except T1 N0)
or R1 or ECE+ or pN2/3
or two of following minor risk factors:
- close margin
- V1
- G3
- Pn1
n.a.
Metastases no distant metastases (M0) n.a.
Other criteria n.a. liver, kidney and other function normal n.a. n.a. n.a. n.a.
Dose in CF Arm 1.8Gyx35Fx =63Gy
5×/week in 7 weeks
2Gyx30Fx = 60Gy 5×/week in 6 weeks 2Gyx33Fx = 66Gy 5×/week in 7 weeks 2Gyx30Fx = 60Gy 5×/week in 6 weeks 1.8Gyx35Fx = 63Gy 5×/week in 7 weeks 2Gyx30-32Fx = 60-64Gy 5×/week in 7 weeks
Dose in AF Arm 1.8Gyx15Fx = 27Gy;5×/week+ 2 × 1.8Gy/d × 10; 5×/week = 63Gy in 35Fx in 5 weeks 3 × 1,4Gy/d = 46,2Gy; 6×/week in 12 days 2Gy×10Fx = 20Gy;5×/week + (1,8Gy + 1,3Gy/d)×15 = 66,5Gy in 40 Fx; in 5 weeks (1.8Gy + 1.4Gy/d)x5Fx +2Gyx15Fx + (2Gy + 1.6Gy/d)x5Fx = 64Gy in 35 Fx 5×/week in 5 weeks 1.8Gyx35Fx = 63Gy; 7×/week in 5 weeks (1.5Gyx3/d)x30Fx = 51-54Gy; 5×/week in 2.4 weeks
  1. ECE Extracapsular extension, CF Conventional fractionation, AF Accelerated fractionation, n.a. Not available, Fx Fractions
  2. aData from the CHARTWEL trial were retrieved from [18]