Table 1 (Reported) Study Inclusion criteria and radiation schedules in the included trials. All Staging is defined by pathology
Ang et al. 2001 [9] | Awwad et al. 2002 [11] | Langendijk et al. 2015 [7] | Sanguineti et al. 2005 [8] | Suwinski et al. 2008 [10] | CHARTWEL unpublisheda | |
|---|---|---|---|---|---|---|
N patients | 151 | 70 | 148 | 226 | 279 | 114 |
Median Follow-up (years; IQR) | 13.8 (8.0–16.9) | 3.8 (1.6–4.7) | 6.3 (5.3–8.0) | 4.5 (3.4–6.2) | 7.2 (6.3–8-0) | 4.8 (3.9–5.4) |
Histology | squamous cell carcinoma | n.a. | ||||
Localisation | oral cavity / oropharynx / hypopharynx / larynx | oral cavity / hypopharynx / larynx | n.a. | oral cavity / oropharynx / hypopharynx / larynx | oral cavity / oropharynx / larynx | oral cavity / oropharynx / hypopharynx / larynx /other |
ECOG PS | ≤ 2 | ≤ 2 | n.a. | ≤ 2 | ≤ 1 | ≤ 2 |
Age (years) | n.a. | ≤ 65 | n.a. | 18–80 | n.a. | n.a. |
Resection | planned | surgical resection without macroscopic residual (R0/R1) | n.a. | |||
Definition of “High Risk” situation | ECE or any two of following: - > 1 nodal group - ≥2 positive nodes - > 3-cm node - Oral cavity - Microscopic pos. Margin - Perineural invasion (Pn1) | - T2/N1–2 or - T3–4/any N | - positive surgical margins and/or - extranodal spread (ECE) | one or more of following risk factors: - pT4 - close margin (< 3 mm) - V1 - L1 - pN2–3 - ECE - time from surgery: ≤ 8 w | all non-laryngeal tumors (except T1 N0) or R1 or ECE+ or pN2/3 or two of following minor risk factors: - close margin - V1 - G3 - Pn1 | n.a. |
Metastases | no distant metastases (M0) | n.a. | ||||
Other criteria | n.a. | liver, kidney and other function normal | n.a. | n.a. | n.a. | n.a. |
Dose in CF Arm | 1.8Gyx35Fx =63Gy 5×/week in 7 weeks | 2Gyx30Fx = 60Gy 5×/week in 6 weeks | 2Gyx33Fx = 66Gy 5×/week in 7 weeks | 2Gyx30Fx = 60Gy 5×/week in 6 weeks | 1.8Gyx35Fx = 63Gy 5×/week in 7 weeks | 2Gyx30-32Fx = 60-64Gy 5×/week in 7 weeks |
Dose in AF Arm | 1.8Gyx15Fx = 27Gy;5×/week+ 2 × 1.8Gy/d × 10; 5×/week = 63Gy in 35Fx in 5 weeks | 3 × 1,4Gy/d = 46,2Gy; 6×/week in 12 days | 2Gy×10Fx = 20Gy;5×/week + (1,8Gy + 1,3Gy/d)×15 = 66,5Gy in 40 Fx; in 5 weeks | (1.8Gy + 1.4Gy/d)x5Fx +2Gyx15Fx + (2Gy + 1.6Gy/d)x5Fx = 64Gy in 35 Fx 5×/week in 5 weeks | 1.8Gyx35Fx = 63Gy; 7×/week in 5 weeks | (1.5Gyx3/d)x30Fx = 51-54Gy; 5×/week in 2.4 weeks |