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Table 1 HA-WBRT Planning acceptability defined by RTOG 0933

From: Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance

  Parameter Per Protocol Acceptable Variation Unacceptable Deviation
HA-WBRT IMRT Planning PTV D2% ≤ 37.5 Gy
D98% ≥ 25 Gy
37.5Gy < D2% ≤ 40Gy
D98% < 25 Gy
V30 < 90%
D2% > 40 Gy
Hippocampus D100% ≤ 9 Gy
Dmax ≤16Gy
D100% ≤ 10 Gy
Dmax ≤17 Gy
D100% >  10 Gy
Dmax > 17 Gy
Optic nerves and chiasm Dmax ≤37.5Gy Dmax ≤37.5Gy Dmax > 37.5Gy
Unscheduled Break Days   0 break days 1–3 break days >  3 break days
  1. Dmax Maximum dose, HA-WBRT Hippocampal avoidance during whole brain radiotherapy, IMRT Intensity-modulated radiotherapy, PTV Planning target volume [13, 22]. Dx% and Vy represent respectively the dose received by x % and the volume received by y Gy of specified structure