Quality assurance analysis of hippocampal avoidance in a melanoma whole brain radiotherapy randomized trial shows good compliance

Table 1 HA-WBRT Planning acceptability defined by RTOG 0933

	Parameter	Per Protocol	Acceptable Variation	Unacceptable Deviation
HA-WBRT IMRT Planning	PTV	D2% ≤ 37.5 Gy D98% ≥ 25 Gy	37.5Gy < D2% ≤ 40Gy D98% < 25 Gy	V30 < 90% D2% > 40 Gy
	Hippocampus	D100% ≤ 9 Gy Dmax ≤16Gy	D100% ≤ 10 Gy Dmax ≤17 Gy	D100% > 10 Gy Dmax > 17 Gy
	Optic nerves and chiasm	Dmax ≤37.5Gy	Dmax ≤37.5Gy	Dmax > 37.5Gy
Unscheduled Break Days		0 break days	1–3 break days	> 3 break days

Dmax Maximum dose, HA-WBRT Hippocampal avoidance during whole brain radiotherapy, IMRT Intensity-modulated radiotherapy, PTV Planning target volume [13, 22]. Dx% and Vy represent respectively the dose received by x % and the volume received by y Gy of specified structure

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