Table 3 Correlation between clinical factors and RP by univariate analysis
Factors | ≥Grade 2 RP | ≥Grade 3 RP | ||||
|---|---|---|---|---|---|---|
No. of RPs/Total (%) | χ2/F | P value | No. of RPs/Total (%) | χ2/F | P value | |
Gender | .078 | 1.000 | 1.616 | .442 | ||
Male | 22/85 (25.9) | 12/85 (14.1) | ||||
Female | 3/10 (30.0) | 0/10 (0) | ||||
Age (year) | .102 | .987 | 1.000 | |||
< 70 | 20/78 (25.6) | 10/78 (12.8) | .014 | |||
≥70 | 5/17 (29.4) | 2/17 (11.8) | ||||
Smoking history (pack-year) | .537 | .464 | 8.035 | .012 | ||
< 40 | 14/59 (23.7) | 3/59 (5.1) | ||||
≥40 | 11/36 (30.6) | 9/36 (25.0) | ||||
Tumor stage | 1.494 | .684 | 3.458 | .122 | ||
IIa | 0/ 1 (0.0) | 0/1 (0.0) | ||||
IIIa | 3/18 (16.7) | 0/18 (0.0) | ||||
IIIb | 15/52 (28.8) | 8/52 (15.4) | ||||
IV | 7/24 (29.2) | 4/24 (16.7) | ||||
Tumor location | .734 | .564 | 1.513 | .391 | ||
Upper or middle lobe | 21/74 (28.4) | 11/74 (14.9) | ||||
Lower lobe | 4/21 (19.0) | 1/21 (0.5) | ||||
Chemotherapy | .177 | .674 | .159 | .984 | ||
Sequential | 19/75 (25.3) | 10/75 (13.3) | ||||
Concurrent | 6/20 (30.0) | 2/20 (10.0) | ||||
Total dose (Gy) | .748 | .592 | 1.151 | .524 | ||
< 54 | 5/14 (35.7) | 3/14 (21.4) | ||||
≥54 | 20/81 (24.7) | 9/81 (11.1) | ||||
FEV1/FVC (%) | .106 | 1.000 | 1.000 | |||
< 70 | 4/25 (16.0) | 2/25 (8.0) | .050 | |||
≥70 | 6/31 (19.4) | 2/31 (6.5) | ||||
FVC (%) | .050 | 1.000 | .747 | |||
< 80 | 4/23 (17.4) | 2/23 (8.7) | 0.858 | |||
≥80 | 5/33 (15.2) | 1/33 (3.0) | ||||
Radiological ILAs | 3.805 | .103 | 6.917 | .027 | ||
Yes | 7/15 (46.7) | 5/15 (33.3) | ||||
No | 18/80 (22.5) | 7/80 (8.8) | ||||