Skip to main content

Table 2 Potential serum biomarkers identified by 1H NMR and their variations among NSCLC patients, MWA treated patients and healthy controls

From: Serum proton NMR metabolomics analysis of human lung cancer following microwave ablation

No.

Metabolites

Chemical shifts (ppm)

NSCLC/CTRL

MWA/NSCLC

MWA/CTRL

fold

p

fold

p

fold

p

1

Isoleucine

0.94 (t), 1.00 (d)

1.09

 

1.18

 

1.29

*

2

Leucine

0.96 (d), 0.97 (d)

1.09

 

0.93

 

1.00

 

3

Valine

0.99 (d), 1.05 (d)

1.11

 

1.17

 

1.30

**

4

Isobutyrate

1.07 (d)

1.06

 

1.09

 

1.16

 

5

Ethanol

1.19 (d), 3.65 (q)

1.01

 

1.11

 

1.12

 

6

3-Hydroxybutyrate

1.20 (d), 2.30, 2.41 (m)

1.15

 

1.09

 

1.25

***

7

Lactate

1.33 (d), 4.12 (q)

2.13

***

0.90

*

1.92

***

8

Alanine

1.48 (d), 3.78 (q)

1.76

***

0.87

*

1.52

***

9

Lysine

1.73 (m), 1.91 (m), 3.30 (t)

1.12

 

1.10

 

1.24

***

10

Acetate

1.92 (s)

1.18

 

1.08

 

1.27

**

11

Proline

2.01 (m)

1.45

**

0.86

 

1.25

**

12

Glycoprotein

2.09 (s)

1.18

*

0.89

 

1.05

 

13

Glutamate

2.05 (m), 2.12 (m), 2.36 (m)

1.14

**

0.85

***

0.96

 

14

Glutamine

2.14 (m), 2.45 (m)

0.80

***

1.11

 

0.89

*

15

Methionine

2.14 (s), 2.65 (t)

1.10

 

1.11

 

1.22

*

16

Acetoacetate

2.28 (s)

1.15

 

1.19

 

1.37

**

17

Pyruvate

2.38 (s)

1.19

 

0.85

 

1.01

 

18

Succinate

2.41 (s)

1.21

 

0.81

 

0.98

 

19

Aspartate

2.68, 2.81 (m)

0.86

 

1.17

 

1.01

 

20

Asparagine

2.87, 2.95 (m)

0.88

 

1.16

 

1.02

 

21

Phosphocreatine

3.04 (s), 3.93 (s)

0.81

***

1.13

 

0.91

 

22

Choline

3.20 (s)

0.89

 

1.07

 

0.95

 

23

O-Acetylcholine

3.21 (s)

0.89

 

0.89

 

0.79

**

24

O-Phosphocholine

3.23 (s)

0.89

 

0.86

 

0.76

***

25

TMAO

3.27 (s)

1.07

 

0.89

 

0.95

 

26

Taurine

3.27 (t), 3.42 (t)

0.76

***

1.38

***

1.05

 

27

Glucose

3.4–3.92 (m)

0.92

*

1.08

*

0.99

 

28

Glycine

3.56 (s)

0.89

*

1.12

*

1.00

 

29

Threonine

3.59 (d), 4.25 (m)

0.82

*

1.20

**

0.98

 

30

Glycerol

3.58, 3.65 (m)

1.24

 

0.82

 

1.01

 

31

dCTP

6.07 (d), 6.08 (t), 7.83 (d)

0.86

 

0.86

 

0.74

***

32

Tyrosine

6.91 (d), 7.20 (d)

1.16

**

0.97

 

1.12

**

33

Phenylalanine

7.33 (d), 7.38 (t), 7.43 (t)

1.17

*

0.83

 

0.97

 

34

Tryptophan

7.55 (d), 7.74 (d)

1.30

***

0.89

 

1.15

**

35

Histidine

7.08 (s), 7.84 (s)

0.88

 

1.14

 

1.00

 

36

Tyramine

7.24 (d)

0.88

 

0.96

 

0.85

**

37

Formate

8.46 (s)

0.87

 

1.12

 

0.98

 
  1. 1H–NMR 1H–nuclear magnetic resonance, NSCLC non-small-cell lung cancer, MWA microwave ablation, TMAO trimethylamine N-oxide. Asterisk P < 0.05, double asterisk P < 0.01 and triple asterisk P < 0.001. Multiplicity: s singlet, d doublet, t triplet, m multiplets
Back to article page

Radiation Oncology

ISSN: 1748-717X

Contact us