Table 5 Late cardiopulmonary toxicities Grade 2 or greater after CRT for esophageal carcinoma on previous reports
Auther Reference year | N | Souce | Radiation dose modality | Radiation techniques | Pleural effusion (%) | Pericardial effusion (%) | Radiation pneumonitis (%) | Other toxicities | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  |  |  | Gr. 2 | Gr. 3-4 | Gr. 2 | Gr. 3-4 | Gr. 2 | Gr. 3-4 | – |
Kato(4) (2011) | 76 | RTOG/EORTC late radiation morbidity scoring scheme | 60 Gy 3DCRT | A-P opposed (initial), bilateral oblique (boost) | 6.6 | 9.2 | 6.6 | 15.8 | 7.9 | 4.2 | – |
Kato(10) (2013) | 51 | CTCAE v. 3.0 | 50.4 Gy 3DCRT | Three or four fields | 14 | 0 | 12 | 0 | 51 | 6 | – |
Ishikura(11) (2003) | 78 | RTOG/EORTC late radiation morbidity scoring scheme | 60Â Gy 3DCRT | A-P opposed (initial), bilateral oblique or multiple (boost) | 9 | 10 | 10 | 10 | 1.3 | 3.8 | Heart Failure Grade4: 2.6% Myocardial Infarction Grade5: 2.6% |
Kumekawa(12) (2006) | 34 | NCI-CTC v. 2.0 RTOG/EORTC late radiation morbidity scoring scheme | 60Â Gy 3DCRT | A-P opposed (initial), bilateral oblique (boost) | 5.9 | 8.9 | 8.9 | 8.9 | 0 | 2.9 | Heart Failure Grade4: 8.9% Cardiac ischema Grade3: 2.9% Grade4: 5.9% |
Morota(13) (2009) | 69 | RTOG/EORTC late radiation morbidity scoring scheme | 60 Gy 3DCRT | A-P opposed (initial), bilateral oblique or multiple (boost) | 13 | 1.5 | – | – | 7.2 | 1.5 | Heart Failure Grade2: 1.5% Grade5: 1.5% Cardiac ischema Grade3: 1.5% Pericarditis Grade3: 1.5% |
Kumar(14) (2012) | 23 | CTCAE v. 3.0 | 50 or 50.4 Gy 3DCRT | Anterior and two lateral beams (initial), anterior and two oblique beams (boost) | – | – | – | – | 74 | 17 | – |