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Table 5 Late cardiopulmonary toxicities Grade 2 or greater after CRT for esophageal carcinoma on previous reports

From: Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma

Auther
Reference
year
N Souce Radiation dose modality Radiation techniques Pleural effusion (%) Pericardial effusion (%) Radiation pneumonitis (%) Other toxicities
      Gr. 2 Gr. 3-4 Gr. 2 Gr. 3-4 Gr. 2 Gr. 3-4
Kato(4) (2011) 76 RTOG/EORTC late radiation morbidity scoring scheme 60 Gy
3DCRT
A-P opposed (initial), bilateral oblique (boost) 6.6 9.2 6.6 15.8 7.9 4.2
Kato(10) (2013) 51 CTCAE v. 3.0 50.4 Gy
3DCRT
Three or four fields 14 0 12 0 51 6
Ishikura(11) (2003) 78 RTOG/EORTC late radiation morbidity scoring scheme 60 Gy
3DCRT
A-P opposed (initial), bilateral oblique or multiple (boost) 9 10 10 10 1.3 3.8 Heart Failure
Grade4: 2.6%
Myocardial Infarction
Grade5: 2.6%
Kumekawa(12) (2006) 34 NCI-CTC v. 2.0
RTOG/EORTC late radiation morbidity scoring scheme
60 Gy
3DCRT
A-P opposed (initial), bilateral oblique (boost) 5.9 8.9 8.9 8.9 0 2.9 Heart Failure
Grade4: 8.9%
Cardiac ischema
Grade3: 2.9%
Grade4: 5.9%
Morota(13) (2009) 69 RTOG/EORTC late radiation morbidity scoring scheme 60 Gy
3DCRT
A-P opposed (initial), bilateral oblique or multiple (boost) 13 1.5 7.2 1.5 Heart Failure
Grade2: 1.5%
Grade5: 1.5%
Cardiac ischema
Grade3: 1.5%
Pericarditis
Grade3: 1.5%
Kumar(14) (2012) 23 CTCAE v. 3.0 50 or 50.4 Gy
3DCRT
Anterior and two lateral beams (initial), anterior and two oblique beams (boost) 74 17
  1. Abbreviations: Gr. Grade, A-P anterior-posterior, CTCAE common terminology criteria for adverse events, RTOG radiation therapy oncology group, EORTC European Organization for Research and Treatment of Cancer, NCI-CTC National Cancer Institute Common Toxicity Criteria, N number of the patients assessed for late toxicities