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Table 5 Late cardiopulmonary toxicities Grade 2 or greater after CRT for esophageal carcinoma on previous reports

From: Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma

Auther

Reference

year

N

Souce

Radiation dose modality

Radiation techniques

Pleural effusion (%)

Pericardial effusion (%)

Radiation pneumonitis (%)

Other toxicities

     

Gr. 2

Gr. 3-4

Gr. 2

Gr. 3-4

Gr. 2

Gr. 3-4

Kato(4) (2011)

76

RTOG/EORTC late radiation morbidity scoring scheme

60 Gy

3DCRT

A-P opposed (initial), bilateral oblique (boost)

6.6

9.2

6.6

15.8

7.9

4.2

Kato(10) (2013)

51

CTCAE v. 3.0

50.4 Gy

3DCRT

Three or four fields

14

0

12

0

51

6

Ishikura(11) (2003)

78

RTOG/EORTC late radiation morbidity scoring scheme

60 Gy

3DCRT

A-P opposed (initial), bilateral oblique or multiple (boost)

9

10

10

10

1.3

3.8

Heart Failure

Grade4: 2.6%

Myocardial Infarction

Grade5: 2.6%

Kumekawa(12) (2006)

34

NCI-CTC v. 2.0

RTOG/EORTC late radiation morbidity scoring scheme

60 Gy

3DCRT

A-P opposed (initial), bilateral oblique (boost)

5.9

8.9

8.9

8.9

0

2.9

Heart Failure

Grade4: 8.9%

Cardiac ischema

Grade3: 2.9%

Grade4: 5.9%

Morota(13) (2009)

69

RTOG/EORTC late radiation morbidity scoring scheme

60 Gy

3DCRT

A-P opposed (initial), bilateral oblique or multiple (boost)

13

1.5

7.2

1.5

Heart Failure

Grade2: 1.5%

Grade5: 1.5%

Cardiac ischema

Grade3: 1.5%

Pericarditis

Grade3: 1.5%

Kumar(14) (2012)

23

CTCAE v. 3.0

50 or 50.4 Gy

3DCRT

Anterior and two lateral beams (initial), anterior and two oblique beams (boost)

74

17

  1. Abbreviations: Gr. Grade, A-P anterior-posterior, CTCAE common terminology criteria for adverse events, RTOG radiation therapy oncology group, EORTC European Organization for Research and Treatment of Cancer, NCI-CTC National Cancer Institute Common Toxicity Criteria, N number of the patients assessed for late toxicities