Optimizing the prescription isodose level in stereotactic volumetric-modulated arc radiotherapy of lung lesions as a potential for dose de-escalation

Table 3 Summary of the biological effective dose (BED) to 95% of the planning target volume (PTV D_95%) and the 3–year local control (LC) rates in the literature

	Prescription	Isodose level at PTV edge	Dose algorithm	Total dose	BED (Gy₁₀) in 3 fractions	BED (Gy₁₀) in 4 fractions	BED (Gy₁₀) in 5 fractions	3-years LC
Aoki et al. [11]	Isocenter	80%	Type-A	50			66.2	95.0%
Onishi et al. [12]								95.0%
Yoshitaki et al. [31]	Isocenter	80%	Type-A	48		62.3		90.0%
Shibamoto et al. [32]								87.0%
Ricardi et al. [33]	PTV edge	80%	Type-A	45	99.0			87.8%
Hassbeek et al. [34]	PTV edge	80%	Type-A	60 60	145.7		108.6	89.3% 89.3%
This study	GTV mean dose	70%	Type-B	54	89.2	76.7	69.1
This study	GTV mean dose	60%	Type-B		74.3	64.4	58.4

Note: BED₁₀ (α / β = 10 Gy) was calculated after adjusting the physical prescription dose by a factor of 0.88 for type–A algorithm with respect to type–B Monte Carlo algorithm according to Ref [37]

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