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Table 4 Multivariate logistic regression analysis for symptomatic radiation pneumonitis (≥ Grade 2)

From: Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis

Parameter

Odds ratio

P Value

V2 (cc)

1.768 (1.056–3.104)

0.0358

V5 (cc)

1.795 (1.071–3.160)

0.0315

V10 (cc)

2.034 (1.196–3.710)

0.0122

V20 (cc)

2.270 (1.309–4.287)

0.0057

V30 (cc)

2.621 (1.482–5.055)

0.0018

V2 − LAV2 (cc)

2.037 (1.175–3.827)

0.0168

V5 − LAV5 (cc)

2.098 (1.192–4.054)

0.0164

V10 − LAV10 (cc)

2.451 (1.344–5.011)

0.0071

V20 − LAV20 (cc)

2.900 (1.525–6.228)

0.0028

V30 − LAV30 (cc)

3.627 (1.852–7.960)

0.0005

LAV2 (cc)

1.058 (0.618–1.718)

0.823

LAV5 (cc)

1.059 (0.615–1.702)

0.822

LAV10 (cc)

1.118 (0.650–1.775)

0.650

LAV20 (cc)

1.143 (0.666–1.791)

0.578

LAV30 (cc)

1.116 (0.640–1.742)

0.652

V2%

2.535 (1.422–4.935)

0.0030

V5%

2.421 (1.360–4.690)

0.0047

V10%

2.957 (1.586–6.188)

0.0016

V20%

3.771 (1.897–8.671)

0.0005

V30%

4.996 (2.392–12.299)

<0.0001

(V2 − LAV2)∕TLV

2.467 (1.384–4.792)

0.0040

(V5 − LAV5)∕TLV

2.376 (1.337–4.168)

0.0054

(V10 – LAV10)∕TLV

2.913 (1.558–6.096)

0.0019

(V20 – LAV20)∕TLV

4.085 (1.984–9.865)

0.0005

(V30 – LAV30)∕TLV

6.114 (2.726–16.873)

<0.0001

(V2 − LAV2)∕(TLV – LAV)

2.810 (1.551–5.621)

0.0015

(V5 – LAV5)∕(TLV – LAV)

2.788 (1.532–5.606)

0.0017

(V10 – LAV10)∕(TLV – LAV)

3.363 (1.756–7.632)

0.0008

(V20 − LAV20)∕(TLV – LAV)

4.319 (2.118–10.368)

0.0003

(V30 – LAV30)∕(TLV – LAV)

5.707 (2.676–14.706)

<0.0001

LAV (cc)

0.758 (0.378–1.351)

0.383

LAV%

0.901 (0.489–1.571)

0.722

TLV – LAV (cc)

0.869 (0.491–1.492)

0.617

MLD (Gy)

3.615 (1.893–7.836)

0.0003

MED (Gy)

1.906 (1.154–3.270)

0.0138

MLWED (Gy)

3.950 (2.042–8.746)

0.0002

  1. The number of symptomatic RP patients / Total patients was 27 / 100
  2. Data were divided by the standard deviation and adjusted for chemotherapy and interstitial lung disease. V2/5/10/20/30 = volume of the lung receiving a dose ≥2/5/10/20/30 Gy, respectively; V2/5/10/20/30% = percentage of lung volume irradiated with ≥2/5/10/20/30 Gy, respectively; LAV2/5/10/20/30 = volume of the lung without low attenuation volume (LAV) receiving 2/5/10/20/30 Gy, respectively; TLV = total lung volume; MLD = mean lung dose; MED = mean emphysema dose; MLWED = mean lung without emphysema dose