The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels

Ou, Xiaomin; Miao, Yibing; Wang, Xiaoshen; Ding, Jianhui; He, Xiayun; Hu, Chaosu

doi:10.1186/s13014-017-0869-x

Table 2 Univariate analysis of risk factors of level IB metastasis in whole cohort and node-positive patients

From: The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels

	Level IB metastasis at diagnosis
	All patients				Node + patients
	Variable	(−), n = 519	(+), n = 13	p value	(−), n = 437	(+), n = 13	p value
N stage	N0	82	0	0.011*	0	0	0.029*
	N1	238	3		238	3
	N2	121	8		121	8
	N3	78	2		78	2
Bilateral nodal metastasis	No	350	3	0.002*	268	3	0.005*
Bilateral nodal metastasis	Yes	169	10		169	10
Nasal cavity involvement	No	402	10	1.000	342	10	1.000
Nasal cavity involvement	Yes	117	3		95	3
Oropharyngeal involvement	No	491	13	1.000	409	13	1.000
Oropharyngeal involvement	Yes	28	0		28	0
Level II involvement	No	129	0	0.045*	47	0	0.378
Level II involvement	Yes	390	13		390	13
Level IIA involvement	No	298	0	0.000*	216	0	0.000*
Level IIA involvement	Yes	221	13		221	13
Level IIB involvement	No	156	2	0.362	74	2	1.000
Level IIB involvement	Yes	363	11		363	11
Level III involvement	No	257	4	0.182	175	4	0.501
Level III involvement	Yes	262	9		262	9
Level VA involvement	No	432	12	0.705	350	12	0.478
Level VA involvement	Yes	87	1		87	1
Level IVA involvement	No	461	11	0.649	379	11	0.687
Level IVA involvement	Yes	58	2		58	2
Level IVB involvement	No	508	13	1.000	426	13	1.000
Level IVB involvement	Yes	11	0		11	0
Level VB involvement	No	509	13	1.000	427	13	1.000
Level VB involvement	Yes	10	0		10	0
Level VC involvement	No	514	13	1.000	432	13	1.000
Level VC involvement	Yes	5	0		5	0
Retropharyngeal nodal (Level VIIA)metastasis	No	252	4	0.205	108	2	0.738
Retropharyngeal nodal (Level VIIA)metastasis	Yes	267	9		326	10
Level VIIB involvement	No	518	13	1.000	436	13	1.000
Level VIIB involvement	Yes	1	0		1	0
Level VIII involvement	No	507	13	1.000	425	13	1.000
Level VIII involvement	Yes	12	0		12	0
Multiple levels involvement (II, III, VA, IVA, VIII)	<2	251	4	0.210	169	4	0.774
Multiple levels involvement (II, III, VA, IVA, VIII)	≥2	268	9		268	9
Level IIA metastasis with multiple levels involvement (II, III, VA, IVA, VIII)	No	355	4	0.007*	273	4	0.038*
	Yes	164	9		164	9
MAD of IIA (mm)	≤20	388	4	0.001*	306	4	0.005*
MAD of IIA (mm)	>20	131	9		131	9
MAD of IIA (mm)	≤30	479	11	0.274	397	11	0.346
MAD of IIA (mm)	>30	40	2		40	2
MAD of neck nodes(mm)	≤30	288	3	0.020*	206	3	0.086
MAD of neck nodes(mm)	>30	231	10		231	10
Necrosis of level IIA nodes	No	463	9	0.048*	381	9	0.081
Necrosis of level IIA nodes	Yes	56	4		56	4
ES of level IIA nodes	No	398	4	0.001*	316	4	0.003*
ES of level IIA nodes	Yes	121	9		121	9
MAD of IIA >20 mm or IIA necrosis	No	373	4	0.003*	291	4	0.014*
MAD of IIA >20 mm or IIA necrosis	Yes	146	9		146	9
MAD of IIA >20 mm or IIA ES	No	363	3	0.001*	281	3	0.006*
MAD of IIA >20 mm or IIA ES	Yes	156	10		156	10

Abbreviation: MAD maximal axial diameter, ES extracapsular spread
*p < 0.05

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ISSN: 1748-717X

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