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Table 3 Complication grades and grade variations following salvage high-dose-rate brachytherapy (a, b) and stereotactic body radiation therapy (c, d) using CTCAE v4.03

From: Salvage prostate re-irradiation using high-dose-rate brachytherapy or focal stereotactic body radiotherapy for local recurrence after definitive radiation therapy

a
HDRB At baseline Maximal acute toxicity Maximal late toxicity At last follow-up
Urinary complication (n, %)
 No complication 5 (50.0) - 2 (20.0) 2 (20.0)
 Grade 1 4 (40.0) 2 (20.0) - 3 (30.0)
 Grade 2 1 (10.0) 7 (70.0) 6 (60.0) 5 (50.0)
 Grade 3 - - 1 (10.0) -
 Grade 4 - - - -
 Not evaluated   1 (10.0) 1 (10.0) -
Digestive complication (n, %)
 No complication 7 (70.0) 8 (80.0) 7 (70.0) 10 (100.0)
 Grade 1 3 (30.0) 1 (10.0) 2 (20.0) -
 Grade 2 - - - -
 Grade 3 - - - -
 Grade 4 - - - -
 Not evaluated - 1 (10.0) 1 (10.0) -
b
HDRB At 3 months At last follow-up
n % n %
Urinary complication
 No modification 2 20.0 4 40.0
  + 1 grade 3 30.0 5 50.0
  + 2 grades 4 40.0 1 10.0
 Not evaluated 1 10.0 - -
Digestive complication
 No modification 9 90.0% 10 100
  + 1 grade - - - -
  + 2 grades - - - -
 Not evaluated 1 10.0% - -
c
SBRT At baseline Maximal acute toxicity Maximal late toxicity At last follow-up
Urinary complication (n, %)
 No complication 8 (44.4) 2 (11.1) 6 (33.3) 4 (22.2)
 Grade 1 5 (27.8) 5 (27.8) 4 (22.2) 6 (33.3)
 Grade 2 3 (16.7) 2 (11.1) 1 (5.6) 3 (16.7)
 Grade 3 1 (5.6) - - -
 Grade 4 - - 1 (5.6) -
 Not evaluated 1 (5.6) 9 (50.0) 6 (33.3) 5 (27.8)
Digestive complication (n, %)
 No complication 13 (72.2) 5 (27.8) 9 (50.0) 10 (55.6)
 Grade 1 1 (5.6) 1 (5.6) - 1 (5.6)
 Grade 2 2 (11.1) 2 (11.1) 1 (5.6) 2 (11.1)
 Grade 3 - - - -
 Grade 4 - - - -
 Not evaluated 2 (11.1) 10 (55.6) 8 (44.4) 5 (27.8)
d
SBRT At 3 months At last follow-up
n % n %
Urinary complication
 No modification 4 22.3 12 66.7
  + 1 grade 4 22.2 1 5.6
  + 2 grades 1 5.6 - -
 Not evaluated 9 50.0 5 27.8
Digestive complication
 No modification 7 38.9 12 66.7
  + 1 grade - - - -
  + 2 grades 1 5.6 - -
 Not evaluated 10 55.6 6 33.3