Table 3 The biological constraints and additional physical constrains used in BMO
Structures | Model or constraints | Parameters | |
|---|---|---|---|
PTV | TCP Poisson-LQ | \( {D}_{50} \) =77.6Gy, \( \gamma \) =1.2, \( \alpha /\beta \) =10Gy | |
Target EUD | D = 54Gy, a = 0.1 | ||
Max Dose | D = 58Gy | ||
Uniformity constraint | Std. dev = 2% | ||
OARs | Rectum | NTCP LKBar | \( {D}_{50} \) =80Gy, \( \gamma \) =3.9, n = 0.06, m = 0.15 |
NTCP LKBbr | \( {D}_{50} \) =81.8Gy, \( \gamma \) =3, n = 0.29, m = 0.22 | ||
NTCP Poisson-LQcr | \( {D}_{50} \) =80Gy, \( \gamma \) =2.2, \( \alpha /\beta \) =3Gy, s = 1 | ||
Max EUD | D (variable), a = 1 | ||
Bladder | NTCP LKBab | \( {D}_{50} \) =62Gy, \( \gamma \) =6, n = 0.13, m = 0.11 | |
NTCP Poisson-LQbb | \( {D}_{50} \) =80Gy, \( \gamma \) =3, \( \alpha /\beta \) =3Gy, s = 0.18 | ||
Max EUD | D (variable), a = 1 | ||
Femur-heads | NTCP Poisson-LQ | \( {D}_{50} \) =65Gy, \( \gamma \) =2.7, \( \alpha /\beta \) =3Gy, s = 1 | |
Max EUD | D (variable), a = 1 | ||
Small bowela | NTCP Poisson-LQ | \( {D}_{50} \) =53.6Gy, \( \gamma \) =2.3, \( \alpha /\beta \) =3Gy, s = 1.5 | |
B-P | Max Dose | D = 50Gy | |