An integrated strategy of biological and physical constraints in biological optimization for cervical carcinoma

Radiation Oncology

Table 2 The physical constraints used in DVO

Structures		Constraints	Parameters
PTV		Min dose	54 Gy
		Dose/volume	V₉₇ > 54.5 Gy
		Dose/volume	V₃ < 57.5 Gy
		Max dose	58 Gy
OAR	Rectum	Dose/volume	V₄₀ < 35 Gy, and two extra dose/volume constraints for reducing the mean dose
	Bladder	Dose/volume	V₄₀ < 35 Gy, and two extra dose/volume constraints for reducing the mean dose
	Femur-heads	Dose/volume	V₅ < 35Gy, and two extra dose/volume constraints for reducing the mean dose
B-P^a		Max dose	50 Gy

^aThe assistance organ Body-PTV (B-P) was defined as the body volume in the CT data set minus the PTV leaving a 0.3 cm gap

ISSN: 1748-717X