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Table 5 Univariate and multivariate analysis results of Grade 2 or higher radiation pneumonitis rate

From: Clinical outcomes of stage I and IIA non-small cell lung cancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system

Variables Grade 2 ≥ Radiation Pneumonitis Univariate Analysis Multivariate Analysis
n Rates (%) OR (95%CI) p-value OR (95%CI) p-value
T stage T1a + T1b 189 13.2 Reference - Reference -
T2a + T2b 86 15.1 1.168 (0.552–2.377) 0.6760 1.381 (0.590–3.121) 0.4485
Histology Adenocarcinoma 177 15.3 1.553 (0.698–3.817) 0.2902 1.492 (0.608–3.963) 0.3896
SCC 77 10.4 Reference - Reference -
Gender Female 69 15.9 1.257 (0.567–2.632) 0.5600 1.298 (0.525–3.099) 0.5643
Male 206 13.1 Reference - Reference -
Location Upper and Middle 160 11.3 Reference - Reference -
Lower 115 17.4 1.661 (0.834–3.329) 0.1481 2.281 (1.042–5.063) 0.0392
BED (10) IC (Gy) ≥90 256 14.5 NE (1.593–NE) 0.0154 NE (1.803–NE) 0.0118
<90 19 0.0 Reference - Reference -
Margins from GTV to PTV (mm) ≥10 151 21.2 6.185 (2.530–18.579) <0.0001 6.479 (2.558–19.988) <0.0001
<10 120 4.2 Reference - Reference -
  1. BED biologically effective dose, CI confidence interval, GTV gross tumor volume, HR hazard ratio, IC isocenter, NE not estimable, PTV planning target volume, SCC squamous cell carcinoma