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Table 3 PTV indices, dose to the brain and to the contralateral hippocampus

From: Hippocampal sparing radiotherapy for glioblastoma patients: a planning study using volumetric modulated arc therapy

 

3D-CRT/median (range)

VMAT/median (range)

p-value

PTV indices

V 95 %

0.88 (0.79–0.97)

0.91 (0.79–0.99)

NS (p = 0.05)

V 100 %

0.53 (0.17–0.75)

0.56 (0.38–0.84)

NS (p = 0.18)

 HI

0.18 (0.09–0.24)

0.15 (0.06–0.21)

p < 0.01

CI 95 %

0.70 (0.32–0.78)

0.80 (0.75–0.91)

p < 0.01

CI 100 %

0.48 (0.15–0.70)

0.55 (0.36–0.78)

NS (p = 0.09)

Brain

Mean dose (Gy)

35.7 (23.7–45.0)

34.0 (24.2–40.3)

p < 0.01

V 12Gy (%)

89.6 (53.5–98.5)

89.2 (70.7–97.3)

p < 0.01

V 30Gy (%)

58.7 (31.3–81.0)

48.2 (27.2–62.4)

p < 0.01

V 45Gy (%)

40.0 (19.0–56.3)

32.9 (17.7–47.7)

p < 0.01

Contralateral hippocampus

Mean dose (Gy)

33.1 (12.1–50.1)

14.7 (8.1–40.3)

p < 0.01

Mean EQD2 (Gy)

25.7 (7.3–46.0)

9.2 (4.6–33.7)

p < 0.01

Max dose (Gy)

39.6 (30.1–59.9)

26.7 (12.6–62.3)

p < 0.01

Max EQD2 (Gy)

32.9 (22.6–59.9)

19.3 (7.6–63.5)

p < 0.01

gEUD (Gy)

36.3 (24.3–56.1)

23.1 (10.8–56.0)

p < 0.01

V 10Gy/5.8Gy(EQD2) (%)

100. (44.3–100.)

100. (14.2–100.)

p < 0.01

V 15Gy/9.4Gy(EQD2) (%)

100. (14.4–100.)

32.3 (0.0–100.)

p < 0.01

V 20Gy/13.3Gy(EQD2) (%)

100. (8.3–100.)

12.6 (0.0–83.0)

p < 0.01

V 30Gy/22.5Gy(EQD2) (%)

70.5 (2.2–100.)

3.4 (0.0–69.0)

p < 0.01

V 40Gy/33.3Gy(EQD2) (%)

1.4 (0.0–100.)

0.4 (0.0–61.3)

p < 0.01