Table 2 Dosimetric comparison between the clinical IMRT plans (of both supine and prone setups) and their knowledge-based re-optimization using the DVH estimation model trained on supine VMAT plans

HI_{_PGTV}

Original

0.04

0.01

0.04

0.05

0.01

0.04

RP-IMRT

0.05

0.01

0.04

0.05

HI_{_PTV}

Original

0.25

0.01

0.24

0.25

0.01

0.01*

RP-IMRT

0.26

0.01

0.25

0.26

CI_{_PGTV}

Original

1.03

0.05

1.01

1.05

0.01

0.61

RP-IMRT

1.02

0.05

1.00

1.04

CI_{_PTV}

Original

1.01

0.02

1.00

1.02

0.17

<0.01*

RP-IMRT

1.18

0.05

1.16

1.20

D_max

Original

52.95

0.44

52.78

53.11

1.51 (2.85 %)

<0.01

RP-IMRT

54.46

1.52

53.89

55.02

D_{2 %}

Original

52.61

0.43

52.44

52.77

0.15 (0.29 %)

0.09

RP-IMRT

52.76

0.51

52.57

52.95

D_{50 %_UB}

Original

33.85

2.96

32.74

34.95

8.76 (25.88 %)

<0.01*

RP-IMRT

25.09

1.32

24.59

25.58

D_{50 %_FH}

Original

15.65

3.33

14.41

16.90

1.92 (12.27 %)

<0.01*

RP-IMRT

13.73

1.43

13.19

14.26

D_{mean_UB}

Original

33.99

2.77

32.95

35.02

7.74 (22.77 %)

<0.01

RP-IMRT

26.25

1.22

25.79

26.70

D_{mean_FH}

Original

16.26

2.74

15.24

17.28

1.64 (10.09)

<0.01

RP-IMRT

14.62

1.10

14.21

15.04

MUs

Original

805

82

774

836

394 (48.94 %)

<0.01*

RP-IMRT

1199

80

1169

1229