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Table 2 Dosimetric comparison between the clinical IMRT plans (of both supine and prone setups) and their knowledge-based re-optimization using the DVH estimation model trained on supine VMAT plans

From: Applying a RapidPlan model trained on a technique and orientation to another: a feasibility and dosimetric evaluation

  Mean SD 95 % Confidence intervals (%) P
Lower Upper
HI_PGTV Original 0.04 0.01 0.04 0.05 0.01 0.04
RP-IMRT 0.05 0.01 0.04 0.05
HI_PTV Original 0.25 0.01 0.24 0.25 0.01 0.01*
RP-IMRT 0.26 0.01 0.25 0.26
CI_PGTV Original 1.03 0.05 1.01 1.05 0.01 0.61
RP-IMRT 1.02 0.05 1.00 1.04
CI_PTV Original 1.01 0.02 1.00 1.02 0.17 <0.01*
RP-IMRT 1.18 0.05 1.16 1.20
Dmax Original 52.95 0.44 52.78 53.11 1.51 (2.85 %) <0.01
RP-IMRT 54.46 1.52 53.89 55.02
D2 % Original 52.61 0.43 52.44 52.77 0.15 (0.29 %) 0.09
RP-IMRT 52.76 0.51 52.57 52.95
D50 %_UB Original 33.85 2.96 32.74 34.95 8.76 (25.88 %) <0.01*
RP-IMRT 25.09 1.32 24.59 25.58
D50 %_FH Original 15.65 3.33 14.41 16.90 1.92 (12.27 %) <0.01*
RP-IMRT 13.73 1.43 13.19 14.26
Dmean_UB Original 33.99 2.77 32.95 35.02 7.74 (22.77 %) <0.01
RP-IMRT 26.25 1.22 25.79 26.70
Dmean_FH Original 16.26 2.74 15.24 17.28 1.64 (10.09) <0.01
RP-IMRT 14.62 1.10 14.21 15.04
MUs Original 805 82 774 836 394 (48.94 %) <0.01*
RP-IMRT 1199 80 1169 1229
  1. Abbreviations: HI homogeneity index, CI conformity index, D max global maximum dose, D 2 % near maximum dose, SD standard deviation, (%) difference between the original and RP-VMAT plans (% relative to the original value), D 50 % dose to the 50 % volume of the structure, D mean mean dose, FH femoral head, UB urinary bladder, MU monitor unit, RP-IMRT intensity modulated radiotherapy plans optimized by RapidPlan. Dose unit (Gy)
  2. *Paired sample T test, otherwise Wilcoxon signed ranks test was used