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Fig. 5 | Radiation Oncology

Fig. 5

From: Temporo-spatial cell-cycle kinetics in HeLa cells irradiated by Ir-192 high dose-rate remote afterloading system (HDR-RALS)

Fig. 5

Quantitative analysis of indices related to cell-cycle kinetics following irradiation. a FGPD for cells at a distance 5 and 20 mm from the Ir-192 source. Control: without irradiation. Data are represented as box-and-whisker plots showing the full range, 25–75 % interquartile range (box), and median (bar) of about 90 cells for each group. **, p < 0.01. b Number of entries into M phase, measured at 5 and 20 mm during the observation period. Data are represented as beeswarm plots from 90 cells for each group. **, p < 0.01. c Proportion of cells undergoing mitotic catastrophe at the indicated distances from the radiation source, expressed as percentages of all cells, including examples as shown in Fig. 4. d Distribution of cell-cycle phases at the time of cell death. Ratios of cell-cycle phases at cell death were determined and expressed as percentages of all dead cells (66 cells at 5 mm; 54 cells at 20 mm)

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