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Fig. 3 | Radiation Oncology

Fig. 3

From: Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo

Fig. 3

PAA-TiOxNPs enhanced the effects of radiation in vitro. a TEM images showing PAA-TiOxNPs within the MIAPaCa-2 cells (red arrows). b, c DNA damage illustrated by immunohistochemistry of γ-H2AX foci in the nucleus. The X-ray irradiation combined with PAA-TiOxNPs induced a higher proportion of γ-H2AX foci-positive cells compared to the single treatment of X-ray irradiation or PAA-TiOxNPs. Data are shown as the mean ± SD. *p < 0.05. d Significantly higher combination effects of X-ray irradiation with PAA-TiOxNPs were observed in a colony forming assay. Data are shown as the mean ± SD from 3 independent experiments. *p < 0.05

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Radiation Oncology

ISSN: 1748-717X

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