Clinical parameters for predicting radiation-induced liver disease after intrahepatic reirradiation for hepatocellular carcinoma

Table 4 Pretreatment liver function before the 1st course of RT and the association with RILD after reirradiation

Variables	RILD (+)	RILD (−)	Univariate
			p value
Total number	13	23
Liver function before 1st RT
Total bilirubin ≧2.0 mg/dL	0	0
Albumin ≦3.5 g/dL	5	3	0.54
Ascites	0	0
INR ≧1.71	0	0
CTP score ≧6	4	2	0.77
AST/ALT ≧3x of upper normal limit	3	2	0.38
Presence of PVTT	5	3	0.75
RT parameters
Mean PTV of the 1st RT (cm³)	605.7 ± 551.5	410.6 ± 667.6	0.41
Mean normal liver dose of 1st RT (EQD₂, Gy₈)	20.8 ± 12.0	21.3 ± 8.7	0.87
Mean normal liver volume of 1st RT (cm³)	1255.5 ± 592.4	1055.3 ± 274.3	0.17

Abbreviation: RILD radiation-induced liver disease, OR odds ratio, CI confidence interval, CTP Child-Turcotte-Pugh, PVTT portal vein tumor thrombosis, AST aspartate aminotransferase, ALT alanine aminotransferase, CTV clinical tumor volume, NS no significance, EQD2 biologically equivalent doses calculated in 2Gy

ISSN: 1748-717X