Table 3 Risk factors associated with lethal RILD after reirradiation

Total number

9

27

 Total bilirubin ≧2.0 mg/dL

4

0

0.002

 Albumin ≦3.5 g/dL

6

6

0.001

 Presence of ascites

3

1

0.014

 INR ≧1.71

0

0

 CTP score ≧6

8

6

<0.001

0.005

72.5554

3.650 ~ 1442.252

 Presence of PVTT

7

6

0.003

 AST/ALT ≧3x of upper normal limit

4

2

0.121

 Hepatitis B infection

5

11

0.439

 Hepatitis C infection

1

7

0.355

 Mean CTV (cm³)

195.2 ± 166.9

186.4 ± 331.7

0.806

 Mean PTV (cm³)

315.5 ± 224.5

285.7 ± 447.7

0.890

 Mean normal liver dose (EQD₂, Gy₈)

9.7 ± 6.8

11.3 ± 5.2

0.019

 Mean normal liver volume (cm³)

1305.8 ± 687.6

975.2 ± 210.5

0.078

 Interval between 2 courses (month)

6.0 ± 8.5

12.7 ± 11.4

0.119

 Mean cumulative normal liver dose (EQD₂, Gy₈)

27.9 ± 12.5

32.2 ± 11.5

0.221

 Mean cumulative prescribed dose (EQD₂, Gy₁₅)

75.0 ± 12.7

92.1 ± 14.7

0.005

 Abutting score for two PTV

1.4 ± 0.8

1.1 ± 0.8

0.824