Table 2 Univariate and multivariate analysis for local control, progression free interval and overall survival according to patient and tumor characteristics

 Prior Therapy

1.38 (0.36–5.33)

0.642

 Histology ^a

<0.001 (0-Inf)

< 0.001

< 0.001 (0-Inf)

0.998

 GTV Volume ^b

0.96 (0.90–1.02)

0.163

 PTV Prescription BED ^b

0.95 (0.92–0.98)

0.002

0.961 (0.921–1.003)

0.069

 GTV Mean BED ^b

0.975 (0.954–0.996)

0.011

0.995 (0.973–1.017)

0.664

 Karnofsky Index ^d

0.51 (0.27–0.98)

0.041

0.81 (0.38–1.73)

0.588

 Gender

0.79 (0.43–1.46)

0.459

n/a

n/a

 Age

0.79 (0.43–1.44)

0.435

n/a

n/a

 Histology ^a

1.20 (0.65–2.21)

0.564

n/a

n/a

 Prior Therapy

2.10 (1.04–4.23)

0.034

1.57 (0.73–3.37)

0.244

 Extra-hepatic Disease Status ^c

3.05 (1.59–5.84)

0.000

2.33 (1.07–5.07)

0.033

 Largest GTV Volume ^b

1.002 (0.998–1.006)

0.283

n/a

n/a

 Cumulative GTV Volume ^b

1.003 (0.999–1.007)

0.110

n/a

n/a

 Number of Treated Metastases

1.77 (0.92–3.41)

0.082

1.19 (0.84–1.76)

0.386

 Karnofsky Index ^d

0.78 (0.37–1.62)

0.496

n/a

n/a

 Gender

0.64 (0.31–1.29)

0.204

n/a

n/a

 Age

0.78 (0.38–1.58)

0.483

n/a

n/a

 Histology ^a

0.74 (0.37–1.48)

0.396

n/a

n/a

 Prior Therapy

1.86 (0.83–4.17)

0.124

n/a

n/a

 Extra-hepatic Disease Status ^c

2.64 (1.30–5.38)

0.005

2.59 (1.26–5.32)

0.009

 Largest GTV Volume ^b

1.003 (0.998–1.008)

0.227

n/a

n/a

 Cumulative GTV Volume ^b

1.004 (0.999–1.009)

0.067

1.004 (0.999–1.009)

0.096

 Number of Treated Metastases

1.29 (0.62–2.67)

0.495

n/a

n/a