Fig. 1

a Clinical 3-year LC data points for the conventionally fracionated and hypofractionated datasets versus BED₁₀ at isocenter with corresponding logistic regression fits of the joint CF + HF dataset, and the CF and HF subsets. Previously published related models are included for comparison: Martel et al. [28] and Guckenberger et al. [61]. b Comparison between the BED₁₀ (isocenter) data points obtained with the LQ and LQ-L fits for the complete dataset and for the hypofractionated subset. The range of experimental data of every model is shown with a continuous line and the extrapolation regions with dashed lines. The levels 80 % TCP and 100 Gy BED₁₀ are also shown for reference