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Table 1 Overview of the patient data related to treatment indication and fractionation. The physics dose limitations for the most common OARs are included together with the delivery technique clinically used in our center

From: Initial characterization, dosimetric benchmark and performance validation of Dynamic Wave Arc

Site Nr. of patients Fractionation Minimum % of PD covering PTV PTV Volume (ccm) OAR Dose constrains Clinical delivery technique
Prostate 3   78Gy(2Gy/fx) >90 % 171.8 [129.8-222.8] Rectum D2% < 74.1 Gy
V70.2Gy < 25 %
V62.4Gy < 50 %
5 IMRT beams
Oligo-metastatic cases 9 5 x1lesion
2x2lesions
2x3lesions
50Gya(5Gy/fx) 100 % 28.0 [12.2-57.5] Lung
Liver
V20Gy < 25 %
V30Gy < 30 %
Dmean < 22 Gy
8-10 CRT beams per lesion
Centrally-located NSCLC 9 6 lesions
3 lesions
48Gyb(12Gy/fx)
60Gy(7.5Gy/fx)
>95 %
>95 %
76.2 [17.2-209.7] Esophagus
Spinal cord
Heart
Proximal- bronchus
Lung
D2% < 30 Gy
D2% < 26 Gy
D2% < 34 Gy
D2% < 34 Gy
V20Gy < (8-10)%
8-10 CRT beams
LAPC 10   48Gy(3.2Gy/fx) >95 % 188.5 [140.6-257.2] Duodenum V39Gy < 1.0 cc
V36Gy < 10 cc
6 IMRT beams
Stomach
Kidney
Liver
V39Gy < 1.0 cc
V36Gy < 10 cc
V20Gy < 30 %
Dmean < 30 Gy
  1. a at 80%isodose
  2. b variable isodose prescriptions
  3. Abbreviations: NSCLC, centrally-located non-small cell lung cancer; LAPC, locally-advanced pancreatic cancer; PD, prescription dose; D 2% near-maximum dose i.e. maximum dose to 2 % of the volume; V xx% , percentage of the volume receiving ≥ xx Gy; V xxGy volume of the structure receiving ≥ xx Gy; D mean , mean dose