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Table 1 Overview of the patient data related to treatment indication and fractionation. The physics dose limitations for the most common OARs are included together with the delivery technique clinically used in our center

From: Initial characterization, dosimetric benchmark and performance validation of Dynamic Wave Arc

Site

Nr. of patients

Fractionation

Minimum % of PD covering PTV

PTV Volume (ccm)

OAR

Dose constrains

Clinical delivery technique

Prostate

3

 

78Gy(2Gy/fx)

>90 %

171.8 [129.8-222.8]

Rectum

D2% < 74.1 Gy

V70.2Gy < 25 %

V62.4Gy < 50 %

5 IMRT beams

Oligo-metastatic cases

9

5 x1lesion

2x2lesions

2x3lesions

50Gya(5Gy/fx)

100 %

28.0 [12.2-57.5]

Lung

Liver

V20Gy < 25 %

V30Gy < 30 %

Dmean < 22 Gy

8-10 CRT beams per lesion

Centrally-located NSCLC

9

6 lesions

3 lesions

48Gyb(12Gy/fx)

60Gy(7.5Gy/fx)

>95 %

>95 %

76.2 [17.2-209.7]

Esophagus

Spinal cord

Heart

Proximal- bronchus

Lung

D2% < 30 Gy

D2% < 26 Gy

D2% < 34 Gy

D2% < 34 Gy

V20Gy < (8-10)%

8-10 CRT beams

LAPC

10

 

48Gy(3.2Gy/fx)

>95 %

188.5 [140.6-257.2]

Duodenum

V39Gy < 1.0 cc

V36Gy < 10 cc

6 IMRT beams

Stomach

Kidney

Liver

V39Gy < 1.0 cc

V36Gy < 10 cc

V20Gy < 30 %

Dmean < 30 Gy

  1. a at 80%isodose
  2. b variable isodose prescriptions
  3. Abbreviations: NSCLC, centrally-located non-small cell lung cancer; LAPC, locally-advanced pancreatic cancer; PD, prescription dose; D 2% near-maximum dose i.e. maximum dose to 2 % of the volume; V xx% , percentage of the volume receiving ≥ xx Gy; V xxGy volume of the structure receiving ≥ xx Gy; D mean , mean dose