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Table 2 Comparison of PTV, heart, lung and NTBTV dosimetric data for 3D-CRT, tomotherapy (TOMO), CyberKnife (CK) and CyberKnife with reduced margins (CKRM). CKRM data are written in bold letters when there are significant differences between CKRM and at least one other technique (only p-values < 0.05 are specified)

From: Accelerated partial breast irradiation using robotic radiotherapy: a dosimetric comparison with tomotherapy and three-dimensional conformal radiotherapy

  3D-CRT TOMO CK CKRM P value CK-RM vs RC3D P value CK-RM vs TM P value CK-RM vs CK
PTV
HI 0.132 ± 0.079 0.097 ± 0.016 0.123 ± 0.01 0.121 ± 0.01    
DSC 0.805 ± 0.047 0.769 ± 0.053 0.850 ± 0.04 0.858 ± 0.03    
D98% (Gy)D2% (Gy) 37.5 ± 3.1 39.8 ± 0.5 38.9 ± 0.9 39.0 ± 0.3    
43.1 ± 0.5 43.8 ± 0.4 44.1 ± 1.1 44.1 ± 0.3    
NTBTV
Dmean (Gy) 11.3 ± 3.7 17.3 ± 4.0 12.3 ± 3.0 9.9 ± 2.0   0.002 0.002
D2% (Gy) 40.5 ± 1.2 40.3 ± 1.2 39.4 ± 1.5 34.6 ± 2.6 0.0020 0.002 0.002
V18Gy (%) 28.6 ± 10.2 45.5 ± 12.5 26.4 ± 8.2 20.7 ± 7.1   0.002 0.0039
V20Gy (%) 27.7 ± 10.1 41.3 ± 12.1 23.3 ± 7.8 17.6 ± 6.5 0.0195 0.0059 0.0039
Homolateral Lung
V5Gy (%) 6.2 ± 2.3 6.6 ± 3.1 9.8 ± 9.5 3.8 ± 6.1    0.002
V10Gy (%) 1.2 ± 0.5 2.3 ± 1.6 2.0 ± 2.9 0.7 ± 1.5   0.0059 0.002
V20Gy (%) 0.2 ± 0.2 0.3 ± 0.5 0.2 ± 0.4 0.0 0.0078 0.0156 0.0312
Heart
V2Gy (%) 4.7 ± 3.4 2.2 ± 3.1 7.5 ± 6.7 3.9 ± 7.6    
V5Gy (%) 0.2 ± 0.4 0.0 ± 0.0 0.3 ± 0.7 0.0 ± 0.0    
Contralateral Breast
D2% (Gy) 0.3 ± 0.2 1.7 ± 1.0 1.3 ± 2.0 1.3 ± 1.8    
  1. PTV planning target volume, NTBTV non-target breast tissue volume, 3D-CRT three-dimensional conformal radiotherapy