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Table 2 Comparison of PTV, heart, lung and NTBTV dosimetric data for 3D-CRT, tomotherapy (TOMO), CyberKnife (CK) and CyberKnife with reduced margins (CKRM). CKRM data are written in bold letters when there are significant differences between CKRM and at least one other technique (only p-values < 0.05 are specified)

From: Accelerated partial breast irradiation using robotic radiotherapy: a dosimetric comparison with tomotherapy and three-dimensional conformal radiotherapy

 

3D-CRT

TOMO

CK

CKRM

P value CK-RM vs RC3D

P value CK-RM vs TM

P value CK-RM vs CK

PTV

HI

0.132 ± 0.079

0.097 ± 0.016

0.123 ± 0.01

0.121 ± 0.01

   

DSC

0.805 ± 0.047

0.769 ± 0.053

0.850 ± 0.04

0.858 ± 0.03

   

D98% (Gy)D2% (Gy)

37.5 ± 3.1

39.8 ± 0.5

38.9 ± 0.9

39.0 ± 0.3

   

43.1 ± 0.5

43.8 ± 0.4

44.1 ± 1.1

44.1 ± 0.3

   

NTBTV

Dmean (Gy)

11.3 ± 3.7

17.3 ± 4.0

12.3 ± 3.0

9.9 ± 2.0

 

0.002

0.002

D2% (Gy)

40.5 ± 1.2

40.3 ± 1.2

39.4 ± 1.5

34.6 ± 2.6

0.0020

0.002

0.002

V18Gy (%)

28.6 ± 10.2

45.5 ± 12.5

26.4 ± 8.2

20.7 ± 7.1

 

0.002

0.0039

V20Gy (%)

27.7 ± 10.1

41.3 ± 12.1

23.3 ± 7.8

17.6 ± 6.5

0.0195

0.0059

0.0039

Homolateral Lung

V5Gy (%)

6.2 ± 2.3

6.6 ± 3.1

9.8 ± 9.5

3.8 ± 6.1

  

0.002

V10Gy (%)

1.2 ± 0.5

2.3 ± 1.6

2.0 ± 2.9

0.7 ± 1.5

 

0.0059

0.002

V20Gy (%)

0.2 ± 0.2

0.3 ± 0.5

0.2 ± 0.4

0.0

0.0078

0.0156

0.0312

Heart

V2Gy (%)

4.7 ± 3.4

2.2 ± 3.1

7.5 ± 6.7

3.9 ± 7.6

   

V5Gy (%)

0.2 ± 0.4

0.0 ± 0.0

0.3 ± 0.7

0.0 ± 0.0

   

Contralateral Breast

D2% (Gy)

0.3 ± 0.2

1.7 ± 1.0

1.3 ± 2.0

1.3 ± 1.8

   
  1. PTV planning target volume, NTBTV non-target breast tissue volume, 3D-CRT three-dimensional conformal radiotherapy