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Table 3 Multivariate analysis for LFFS, DMFS and OS

From: The efficacy of postoperative radiotherapy in localized primary soft tissue sarcoma treated with conservative surgery

  LFFS DMFS OS
Characteristic HR (95 % CI) P* HR (95 % CI) p HR (95 % CI)  
Age (>50 vs. ≤50)   0.980   0.774   0.210
Gender   0.602   0.780   0.794
Location   0.560   0.453   0.506
Histology   0.621   <0.001   <0.001
 Rhabdomyosarcoma    1.00   1.00  
 Fibrosarcoma    0.128 (0.029–0.569) 0.012 0.142 (0.039–0.510) 0.003
 MFH    0.574 (0.281–1.174) 0.088 0.516 (0.254–1.047) 0.067
 Liposarcoma    0.161 (0.069–0.378) <0.001 0.186 (0.088–0.392) <0.001
 Others    0.407 (0.154–1.074) 0.074 0.426 (0.169–1.073) 0.070
Tumor size (cm)   0.033   0.066   0.003
 ≤5 1.00     1.00  
 >5 1.815 (1051–3.138)     2.638 (1.392–4.998)  
Grade   0.147   0.259   0.400
Margin status   0.002   0.143   <0.001
 Negative 1.00   1.00   1.00  
 Positive 2.595 (1.432–4.702)   2.187 (1.055–4.536)   3.942 (2.233–6.959)  
Lymph node status   0.909   0.272   0.582
Chemotherapy   0.687   0.894   0.719
Radiotherapy   0.001   0.769   0.017
 No 1.00     1.00  
 Yes 0.408 (0.235–0.707)     0.512 (0.296–0.886)  
  1. Abbreviations: HR hazard ratio, CI confidence interval, OS overall survival, LFFS local failure-free survival, DMFS distant metastasis-free survival
  2. *Determined by Cox logistic regression method