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Table 5 Binary regression analyses addressing the impact of hippocampal dosimetric parameters on patients’ verbal memory

From: Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study

NCF tests Dosimetric parameters Crude OR (p-value) Adjusted OR Statistical significance 95 % CI
WLL-IR
  R-hippo mean 2.232 (p = 0.108) 2.901 0.077 0.893–9.424
  R-hippo max 1.026 (p = 0.856) 1.040 0.802 0.763–1.419
  R-hippo min 4.380 (p = 0.077) 5.818 0.061 0.920–36.805
  L-hippo mean 2.870 (p = 0.060) 4.080 0.0420* 1.055–15.780
  L-hippo max 1.003 (p = 0.975) 1.012 0.920 0.802–1.276
  L-hippo min 7.903 (p = 0.037*) 14.345 0.040* 1.126–182.689
  B-hippo mean 2.569 (p = 0.076) 3.510 0.052 0.989–12.460
  B-hippo max 1.004 (p = 0.974) 1.011 0.930 0.797–1.282
  B-hippo min 5.333 (p = 0.070) 8.147 0.060 0.917–72.401
WLL-LTDR
  R-hippo mean 1.114 (p = 0.805) 1.169 0.769 0.413–3.313
  R-hippo max 0.894 (p = 0.551) 0.883 0.652 0.513–1.519
  R-hippo min 1.203 (p = 0.784) 1.339 0.716 0.277–6.481
  L-hippo mean 1.218 (p = 0.665) 1.366 0.581 0.452–4.129
  L-hippo max 0.926 (p = 0.596) 0.973 0.864 0.711–1.332
  L-hippo min 1.784 (p = 0.352) 2.249 0.322 0.453–11.178
  B-hippo mean 1.176 (p = 0.718) 1.291 0.643 0.438–3.809
  B-hippo max 0.918 (p = 0.574) 0.938 0.738 0.644–1.366
  B-hippo min 1.349 (p = 0.672) 1.612 0.584 0.292–8.897
WLL-R
  R-hippo mean 0.994 (p = 0.990) 1.262 0.699 0.389–4.093
  R-hippo max 1.321 (p = 0.183) 3.091 0.147 0.671–14.232
  R-hippo min 1.481 (p = 0.616) 1.966 0.430 0.367–10.528
  L-hippo mean 1.177 (p = 0.757) 1.573 0.460 0.473–5.234
  L-hippo max 1.370 (p = 0.209) 2.290 0.084 0.894–5.868
  L-hippo min 1.669 (p = 0.465) 2.199 0.357 0.412–11.746
  B-hippo mean 1.089 (p = 0.870) 1.424 0.563 0.430–4.718
  B-hippo max 1.309 (p = 0.214) 2.308 0.114 0.817–6.521
  B-hippo min 1.632 (p = 0.551) 2.273 0.363 0.388–13.305
  1. Abbreviations: WLL word list learning of Wechsler memory scale-III, IR immediate recall, LTDR long term delayed recall, R recognition, R-hippo right hippocampus, L-hippo left hippocampus, B-hippo bilateral hippocampi as a composite structure, OR odds ratio, CI confidence Interval
  2. The NCF test results shown here are derived from of Wechsler Memory Scale-III Word Lists
  3. Adjusted OR represents the independent effect of the dosimetric parameter of interest after controlling for the patient’s age at study recruitment and whether craniotomy with tumor removal was performed or not before the referral to our Department of Radiation Oncology
  4. The status of neurocognitive change shown here is according to patients’ performance on verbal memory indicated by Wechsler Memory Scale-III Word Lists
  5. * indicates that statistical significance is noted