Skip to main content

Table 3 Correlation of hippocampal dosimetry with the status of NCF change in verbal memory after HS-WBRT

From: Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study

Dosimetric parameters Dosimetric cut-off points NCF Preservation N (%) No preservation p value
Bilateral hippocampi as a composite structure
Maximum ≤12.6 Gy 10(83.3 %) 2(16.7 %) 0.004*
>12.6 Gy 3(25.0 %) 9(75.0 %)
 D10% ≤8.81 Gy 9(75.0 %) 3(25.0 %) 0.041*
>8.81 Gy 4(33.3 %) 8(66.7 %)
 D20% ≤8.26 Gy 8(66.7 %) 4(33.3 %) 0.219
>8.26 Gy 5(41.7 %) 7(58.3 %)
 D30% ≤7.95 Gy 8(66.7 %) 4(33.3 %) 0.219
>7.95 Gy 5(41.7 %) 7(58.3 %)
 D40% ≤7.68 Gy 8(66.7 %) 4(33.3 %) 0.219
>7.68 Gy 5(41.7 %) 7(58.3 %)
 D50% ≤7.45 Gy 9(75.0 %) 3(25.0 %) 0.041*
>7.45 Gy 4(33.3 %) 8(66.7 %)
 D80% ≤6.80 Gy 9(75.0 %) 3(25.0 %) 0.041*
>6.80 Gy 4(33.3 %) 8(66.7 %)
 D100% ≤5.83 Gy 9(75.0 %) 3(25.0 %) 0.041*
>5.83 Gy 4(33.3 %) 8(66.7 %)
Left hippocampus
Maximum ≤12.41 Gy 10(83.3 %) 2(16.7 %) 0.004*
>12.41 Gy 3(25.0 %) 9(75.0 %)
 D10% ≤8.75 Gy 9(75.0 %) 3(25.0 %) 0.041*
>8.75 Gy 4(33.3 %) 8(66.7 %)
 D20% ≤8.22 Gy 8(66.7 %) 4(33.3 %) 0.219
>8.22 Gy 5(41.7 %) 7(58.3 %)
 D30% ≤7.94 Gy 8(66.7 %) 4(33.3 %) 0.219
>7.94 Gy 5(41.7 %) 7(58.3 %)
 D40% ≤7.70 Gy 9(75.0 %) 3(25.0 %) 0.041*
>7.70 Gy 4(33.3 %) 8(66.7 %)
 D50% ≤7.48 Gy 9(75.0 %) 3(25.0 %) 0.041*
>7.48 Gy 4(33.3 %) 8(66.7 %)
 D80% ≤6.73 Gy 9(75.0 %) 3(25.0 %) 0.041*
>6.73 Gy 4(33.3 %) 8(66.7 %)
 D100% ≤5.73 Gy 8(66.7 %) 4(33.3 %) 0.219
>5.73 Gy 5(41.7 %) 7(58.3 %)  
  1. The status of neurocognitive change shown here is according to patients’ performance on the immediate recall of Wechsler Memory Scale-III Word Lists. The association between hippocampal dosimetry and the status of NCF change (preservation or not) in verbal memory 4 months after the HS-WBRT course was evaluated by using chi-square test for the 24 patients in whom post-treatment NCF assessment was available
  2. The N (%) is listed to stand for the number of patients and its corresponding percentage
  3. * indicates that statistical significance is noted