Table 3 Multivariate analysis of prognostic factors that influence PFS, CSS, and OS

Age

0.42

0.32

0.96

 <75

1

1

1

 ≥75

0.82 (0.51-1.33)

0.70 (0.34-1.42)

1.01 (0.62-1.66)

Sex

0.66

0.81

0.86

 M

1

1

1

 F

0.83 (0.35-1.94)

0.86 (0.24-3.08)

1.08 (0.45-2.58)

ECOG PS

0.27

0.14

0.90

 0-1

1

1

1

 2-3

1.33 (0.80-2.19)

1.66 (0.84-3.27)

1.56 (0.93-2.60)

^aFEV1(%)

0.63

0.96

0.42

 ≥70

1

1

1

 <70

0.88 (0.54-1.45)

1.02 (0.52-2.00)

0.81 (0.49-1.34)

Pathology

 Squamous cell carcinoma

1

1

1

 Adenocarcinoma

1.25 (0.56-2.79)

0.59

1.63 (0.62-4.29)

0.32

1.32 (0.60-2.91)

0.49

 Others

0.93 (0.35-2.48)

0.88

0.70 (0.17-2.92)

0.63

0.78 (0.28-2.16)

0.64

Tumor size

0.11

0.50

0.20

<7 c m

1

1

1

 ≥7 c m

0.60 (0.32-1.11)

0.75 (0.33-1.72)

0.65 (0.34-1.25)

T-stage

0.02

0.12

0.08

 1-2

1

1

1

 3-4

2.00 (1.11-3.61)

1.90 (0.85-4.26)

1.67 (0.93-2.98)

N-stage

0.18

0.30

0.29

 0-1

1

1

1

 2-3

1.42 (0.85-2.39)

1.46 (0.72-2.97)

1.33 (0.79-2.26)

Initial response

0.02

0.02

0.07

 CR or PR

1

1

1

 SD or PD

2.03 (1.15-3.58)

2.40 (1.16-4.98)

1.68 (0.96-2.94)