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Table 2 Summary of meta-analysis results for the association between ERCC2 polymorphisms and radiotoxicity

From: ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis

Variable No. of cohorts Cases/Total OR [95 % CI]a P z-test I 2 (%) P het Power (%)
rs13181
Dominant model 9 342/1486 0.71 [0.55, 0.93] 0.01 0 0.59 79.2
 Early adverse effect 8 325/1417 0.72 [0.55, 0.94] 0.02 0 0.49 73.8
 Acute skin toxicity 4 219/895 0.85 [0.61, 1.20] 0.36 0 0.43 18.0
 Acute esophageal toxicity 2 70/273 0.56 [0.32, 0.97] 0.04 0 0.49 54.6
 Acute gastrointestinal toxicity 2 36/249 0.44 [0.19, 1.02] 0.06 0 0.87 52.7
Recessive model 5 286/1090 0.75 [0.50, 1.12] 0.16 43 0.14 27.4
Allelic model 5 286/1090 0.78 [0.64, 0.97] 0.02 27 0.24 68.5
rs1799793
Dominant model 5 256/1687 1.15 [0.86, 1.53] 0.34 0 0.41 16.9
 Early adverse effect 4 130/1287 1.36 [0.96, 1.92] 0.09 0 0.75 35.2
 Acute skin toxicity 2 84/529 1.48 [0.97, 2.26] 0.07 0 0.42 31.9
Recessive model 3 236/1540 0.67 [0.41, 1.08] 0.10 0 0.49 38.9
Allelic model 3 236/1540 0.99 [0.80, 1.23] 0.95 44 0.17 5.1
rs1052555
Dominant model 2 46/758 0.98 [0.53, 1.80] 0.95 0 0.74 5.1
  1. P Z-test: P value of Z-Test for overall effect
  2. P het: P value of Chi2 based Q-test for heterogeneity
  3. aFixed-effect model used