|
Variable
|
No. of cohorts
|
Cases/Total
|
OR [95 % CI]a
|
P
z-test
|
I
2 (%)
|
P
het
|
Power (%)
|
|---|
|
rs13181
|
|
Dominant model
|
9
|
342/1486
|
0.71 [0.55, 0.93]
|
0.01
|
0
|
0.59
|
79.2
|
|
Early adverse effect
|
8
|
325/1417
|
0.72 [0.55, 0.94]
|
0.02
|
0
|
0.49
|
73.8
|
|
Acute skin toxicity
|
4
|
219/895
|
0.85 [0.61, 1.20]
|
0.36
|
0
|
0.43
|
18.0
|
|
Acute esophageal toxicity
|
2
|
70/273
|
0.56 [0.32, 0.97]
|
0.04
|
0
|
0.49
|
54.6
|
|
Acute gastrointestinal toxicity
|
2
|
36/249
|
0.44 [0.19, 1.02]
|
0.06
|
0
|
0.87
|
52.7
|
|
Recessive model
|
5
|
286/1090
|
0.75 [0.50, 1.12]
|
0.16
|
43
|
0.14
|
27.4
|
|
Allelic model
|
5
|
286/1090
|
0.78 [0.64, 0.97]
|
0.02
|
27
|
0.24
|
68.5
|
|
rs1799793
|
|
Dominant model
|
5
|
256/1687
|
1.15 [0.86, 1.53]
|
0.34
|
0
|
0.41
|
16.9
|
|
Early adverse effect
|
4
|
130/1287
|
1.36 [0.96, 1.92]
|
0.09
|
0
|
0.75
|
35.2
|
|
Acute skin toxicity
|
2
|
84/529
|
1.48 [0.97, 2.26]
|
0.07
|
0
|
0.42
|
31.9
|
|
Recessive model
|
3
|
236/1540
|
0.67 [0.41, 1.08]
|
0.10
|
0
|
0.49
|
38.9
|
|
Allelic model
|
3
|
236/1540
|
0.99 [0.80, 1.23]
|
0.95
|
44
|
0.17
|
5.1
|
|
rs1052555
|
|
Dominant model
|
2
|
46/758
|
0.98 [0.53, 1.80]
|
0.95
|
0
|
0.74
|
5.1
|
-
P
Z-test: P value of Z-Test for overall effect
-
P
het: P value of Chi2 based Q-test for heterogeneity
-
aFixed-effect model used
