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Table 1 Baseline Characteristics of the Eligible Studies

From: ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis

Author, Year Country Ethnicity Disease Adverse Effect Assessment Criteria SNP MAF Sample Size EBRT Dose, Gy
Chang-Claude 2005 [40] Germany Caucasian Breast cancer Early effect: acute skin toxicity RTOG/EORTC ≥ G2 rs13181, rs1799793 0.378,0.368 441 50-60
Chang-Claude 2009 [41] Germany Caucasian Breast cancer Late effect: telangiectasia RTOG/EORTC ≥ G2 rs1799793 0.363 400 50-60
Duldulao 2013 [42] USA NR Rectal cancer Early effect: gastrointestinal and abdominal toxicity CTCAE v3.0 ≥ G3 rs13181 0.276 156 50.4-54
Fachal 2012 [43] Spain Caucasian Prostate cancer Early effect: gastrointestinal toxicity CTCAE v2.0 ≥ G2 rs1799793, rs1052555 0.342,0.328 698 70-76
Mangoni 2011 [44] Italy Caucasian Breast cancer Early effect: acute skin toxicity CTCAE v2.0 ≥ G2ca rs13181, rs1799793 NA 87 50-62.8
Raabe 2012 [45] Germany NR Breast cancer Early effect: acute skin toxicity RTOG/EORTC ≥ G2 rs13181 0.646 82 50.4
Sakano 2010 [46] Japan Asian Bladder cancer Early effect: diarrhea CTCAE v3.0 ≥ G2 rs13181 NA 93 30.0-60.4
Terrazzino 2012 [47] Italy Caucasian Breast cancer Early effect: acute skin toxicity RTOG/EORTC ≥ G2 rs13181 0.365 285 50-66
Yoon 2011 [48] USA Mixedb Esophageal cancer Early effect: esophageal toxicity and myelosuppression RTOG/EORTC ≥ G3 rs13181, rs1799793, rs1052555 NA 60 46
Zhang 2010 [49] China NR Lung cancer Early effect: esophageal toxicity NR v2.0 ≥ G2 rs13181 0.286 213 50-70
Zschenker 2010 [50] Germany NR Breast cancer Late effect: fibrosis LENT/SOMA ≥ G2 rs13181 0.551 69 54-55
  1. Abbreviations: MAF minor allele frequency, RTOG the radiation therapy oncology group, EORTC European Organization for Research and Treatment of Cancer, EBRT external beam radiation therapy, CTCAE Common Terminology Criteria for Adverse Events. NR not related. NA not available. SNP single nucleotide polymorphism
  2. amethod based on CTCAE, in which G2c was defined as at least one moist desquamation or interruption of radiotherapy due to toxicity. bCaucasian account for 93 %