ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis

Table 1 Baseline Characteristics of the Eligible Studies

Author, Year	Country	Ethnicity	Disease	Adverse Effect	Assessment Criteria	SNP	MAF	Sample Size	EBRT Dose, Gy
Chang-Claude 2005 [40]	Germany	Caucasian	Breast cancer	Early effect: acute skin toxicity	RTOG/EORTC ≥ G2	rs13181, rs1799793	0.378,0.368	441	50-60
Chang-Claude 2009 [41]	Germany	Caucasian	Breast cancer	Late effect: telangiectasia	RTOG/EORTC ≥ G2	rs1799793	0.363	400	50-60
Duldulao 2013 [42]	USA	NR	Rectal cancer	Early effect: gastrointestinal and abdominal toxicity	CTCAE v3.0 ≥ G3	rs13181	0.276	156	50.4-54
Fachal 2012 [43]	Spain	Caucasian	Prostate cancer	Early effect: gastrointestinal toxicity	CTCAE v2.0 ≥ G2	rs1799793, rs1052555	0.342,0.328	698	70-76
Mangoni 2011 [44]	Italy	Caucasian	Breast cancer	Early effect: acute skin toxicity	CTCAE v2.0 ≥ G2c^a	rs13181, rs1799793	NA	87	50-62.8
Raabe 2012 [45]	Germany	NR	Breast cancer	Early effect: acute skin toxicity	RTOG/EORTC ≥ G2	rs13181	0.646	82	50.4
Sakano 2010 [46]	Japan	Asian	Bladder cancer	Early effect: diarrhea	CTCAE v3.0 ≥ G2	rs13181	NA	93	30.0-60.4
Terrazzino 2012 [47]	Italy	Caucasian	Breast cancer	Early effect: acute skin toxicity	RTOG/EORTC ≥ G2	rs13181	0.365	285	50-66
Yoon 2011 [48]	USA	Mixed^b	Esophageal cancer	Early effect: esophageal toxicity and myelosuppression	RTOG/EORTC ≥ G3	rs13181, rs1799793, rs1052555	NA	60	46
Zhang 2010 [49]	China	NR	Lung cancer	Early effect: esophageal toxicity	NR v2.0 ≥ G2	rs13181	0.286	213	50-70
Zschenker 2010 [50]	Germany	NR	Breast cancer	Late effect: fibrosis	LENT/SOMA ≥ G2	rs13181	0.551	69	54-55

Abbreviations: MAF minor allele frequency, RTOG the radiation therapy oncology group, EORTC European Organization for Research and Treatment of Cancer, EBRT external beam radiation therapy, CTCAE Common Terminology Criteria for Adverse Events. NR not related. NA not available. SNP single nucleotide polymorphism
^amethod based on CTCAE, in which G2c was defined as at least one moist desquamation or interruption of radiotherapy due to toxicity. ^bCaucasian account for 93 %

ISSN: 1748-717X