Table 2 Dose volume metrics for all radiotherapy plans
Comparison of dose-volume metrics, TCP and NTCP values | ||||||
|---|---|---|---|---|---|---|
50Gy3D | 50GyRA | 60GyRA | Wilcoxon signed-rank test | |||
Median (range) | Median (range) | Median (range) | 50Gy3D–50GyRA | 50Gy3D–60GyRA | 50GyRA–60GyRA | |
PTV1 | ||||||
V95% | 98.2 (96.0–100) | 99.1 (95.2–100) | 97.0 (95.0–98.2) | Z = 0.53 (p = .57) | Z = 1.07 (p = .28) | Z = 1.36 (p = .17) |
PTV2 (GTV + 0.5 cm) | ||||||
V95% | 95.1 (92.4–97.4) | |||||
TCP (%) Geh | 38.7 (37.5–41.1) | 37.8 (37.5–38.7) | 50.9 (50.7–51.4) | Z = 2.11 (p = .04) | Z = 2.67 (p = .01) | Z = 2.81 (p = .01) |
Lung | ||||||
Mean dose (Gy) | 9.8 (6.0–11.1) | 10.2 (5.8–14.3) | 10.7 (6.4–15.2) | Z = 1.78 (p = .07) | Z = 2.40 (p = .02) | Z = 2.80 (p = .01) |
V13Gy (%) | 26.8 (20.0–35.9) | 32.8 (15.1–51.6) | 34.4 (18.0–54.2) | Z = 2.19 (p = .03) | Z = 2.55 (p = .01) | Z = 2.09 (p = .04) |
V20Gy (%) | 19.7 (12.3–24.3) | 11.3 (4.6–17.4) | 15.6 (6.5–23.4) | Z = 2.55 (p = .01) | Z = 1.72 (p = .09) | Z = 2.81 (p = .01) |
NTCP (%) De Jaeger | 5.1 (1.9–6.0) | 4.3 (2.8–8.0) | 4.7 (3.1–9.0) | Z = 1.49 (p = .14) | Z = 2.09 (p = .04) | Z = 2.80 (p = .01) |
Heart | ||||||
Mean dose (Gy) | 26.8 (13.9–31.2) | 21.2 (14.6–23.6) | 20.2 (16.4–23.2) | Z = 1.68 (p = .09) | Z = 1.58 (p = .11) | Z = 0.15 (p = .88) |
V30Gy (%) | 55.1 (9.7–67.9) | 17.2 (8.2–25.3) | 18.7 (10.3–22.6) | Z = 2.67 (p = .01) | Z = 2.55 (p = .01) | Z = 0.87 (p = .39) |
V40Gy (%) | 16.2 (5.9–24.5) | 10.1 (4.5–14.8) | 10.6 (5.6–13.6) | Z = 2.67 (p = .01) | Z = 2.67 (p = .01) | Z = 1.58 (p = .11) |
NTCP (%) Gagliardi | 8.9 (3.1–12.8) | 4.9 (2.2–7.3) | 6.1 (2.9–7.9) | Z = 1.90 (p = .06) | Z = 1.38 (p = .17) | Z = 2.80 (p = .01) |
Stomach | ||||||
Mean dose (Gy) | 29.8 (5.5–44.2) | 24.1 (5.4–40.4) | 23 (6.5–36.1) | Z = 1.17 (p = .24) | Z = 0.97 (p = .33) | Z = 1.60 (p = .11) |
Max dose (Gy) | 52.6 (49.6–53.4) | 51.9 (42.4–52.9) | 60.9 (51.6–61.6) | Z = 0.83 (p = .41) | Z = 2.61 (p = .01) | Z = 2.81 (p = .01) |
V45 (cc) | 47.3 (7.3–80.4) | 32.8 (0–49.8) | 34.3 (5.4–25.4) | Z = 2.60 (p = .01) | Z = 2.50 (p = .01) | Z = 0.36 (p = .72) |
V50 (cc) | 31.5 (0–23.4) | 17.7 (0–14.8) | 21.4 (2.2–19.2) | Z = 2.31 (p = .02) | Z = 1.78 (p = .07) | Z = 1.27 (p = .20) |
StomachIn max dose (Gy) | 52.6 (49.6–53.4) | 51.9 (42.4–52.9) | 60.9 (51.6–61.6) | Z = 0.77 (p = .44) | Z = 2.61 (p = .01) | Z = 2.81 (p = .01) |
StomachOut max dose (Gy) | 51.4 (49.4–53.1) | 44.4 (36.6–43.6) | 44.8 (42.3–46.1) | Z = 1.76 (p = .07) | Z = 1.79 (p = .07) | Z = 0.14 (p = .88) |
NTCP (%) Burman | 0.6 (0–2.5) | 0.2 (0–1.3) | 0.3 (0–3.4) | Z = 2.38 (p = .02) | Z = 0.35 (p = .73) | Z = 2.03 (p = .04) |
Stomach wall | ||||||
Mean dose (Gy) | 29.5 (8.2–42.6) | 22.9 (7.9–38.7) | 22.4 (9.1–35.0) | Z = 0.97 (p = .33) | Z = 0.76 (p = .45) | Z = 0.87 (p = .39) |
Max dose (Gy) | 52.6 (49.6–53.4) | 51.9 (43.4–52.9) | 61 (51.6–61.6) | Z = 0.77 (p = .44) | Z = 2.55 (p = .01) | Z = 2.81 (p = .01) |
V45 (cc) | 28 (6.2–39.9) | 17.9 (0–26.9) | 17.9 (5.4–25.4) | Z = 2.19 (p = .03) | Z = 2.19 (p = .03) | Z = 0.46 (p = .65) |
V50 (cc) | 15.8 (0–23.4) | 9.1 (0–14.8) | 9.2 (2.2–19.2) | Z = 2.31 (p = .02) | Z = 1.48 (p = .14) | Z = 1.28 (p = .20) |
NTCP (%) Feng | 17.4 (3.5–24.9) | 11.1 (3.6–18.9) | 17.5 (3.2–39.4) | Z = 1.72 (p = .09) | Z = 1.99 (p = .05) | Z = 2.70 (p = .01) |
Cord PRV | ||||||
Dmax 0.1 cc (Gy) | 36.9 (16.1–41.3) | 31.1 (26.2–44.1) | 34.9 (28.4–39.6) | Z = 0.47 (p = .64) | Z = 0.18 (p = .86) | Z = 1.67 (p = .10) |