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Table 4 Treatment toxicity and the sites of first failure for the two patient groups (EBRT + NBT and 3D-CRT)

From: A retrospective study of californium-252 neutron brachytherapy combined with EBRT versus 3D-CRT in the treatment of esophageal squamous cell cancer

Characteristics EBRT + NBT (n = 545) 3D-CRT (n = 339) P value
Acute toxicity (Events of grade ≥2) Number of patients (%)
 Esophagitis 197 (36.1 %) 122 36.0 %) 0.962
 Pulmonary complications 30 (5.5 %) 10 (2.9 %) 0.076
 Leukopenia 425 (78.0 %) 209 (61.7 %) <0.001
 Neutropenia 282 (51.7 %) 165 (48.7 %) 0.375
 Thrombocytopenia 54 (9.9 %) 8 (2.4 %) <0.001
Late toxicity    
 Esophageal fistulas 33 (6.1 %) 47 (13.9 %) <0.001
 Massive bleeding 27 (5.0 %) 20 (5.9 %) 0.831
The sites of first failure in the whole group    
 Local-regional failure 195 (35.7 %) 139 (41.0 %) 0.001
 In field 170 (31.2 %) 124 (36.6 %) 0.001
 Out field 25 (4.6 %) 15 (4.4 %) 0.116
 Distant metastasis 86 (15.8 %) 41 (12.1 %) 0.128
 Lung 23 (4.2 %) 14 (4.1 %) NS
liver 14 (2.6 %) 8 (2.4 %) NS
 Bone 14 (2.6 %) 3 (0.9 %) NS
 Brain 5 (1.0 %) 3 (0.9 %) NS
 ≥2 metastasis sites 30 (5.5 %) 13 (3.8 %) NS
Not otherwise specified (disease of heart head blood-vessel, pneumonia, second tumor) 36 (6.6 %) 35 (6.4 %) NS
  1. Abbreviations: EBRT + NBT external beam radiotherapy plus neutron brachytherapy; 3D-CRT three dimensional conformal radiotherapy; NS no statistics