Fig. 3

Results of immunohistochemical analysis. a Histological photograph of vWF staining in non-irradiated cervical skin. Scale bar = 50 μm. b Histological photograph of vWF staining in irradiated cervical skin. Scale bar = 50 μm. (c + d) Boxplot diagrams visualizing the number of stained vessels per high power field (HPF) (c); and the measured thickness of the epidermis (d). Given is the median value, (with the 75th percentile and the 25th percentile) calculated over ten HPFs in patients with (n = 27) and without RT (n = 57). The range is shown as a vertical line; extreme values are excluded. P-values were calculated by means of the Mann–Whitney test. Statistical significance between groups could be shown (both *: p = 0.000)