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Table 4 Multivariate analyses of progression free survival

From: Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme

PFS

All patients

Fractionation 33 × 1.8 Gy

Fractionation 30 × 2.0 Gy

Factor

HR (95 % CI)

p-value

HR (95 % CI)

p-value

HR (95 % CI)

p-value

Interval surgery → RCT

1.000 (0.991-1.010)

0.943

0.999 (0.985-1.014)

0.896

1.000 (0.987-1.014)

0.984

Age

1.021 (1.010-1.032)

<0.001

1.022 (1.007-1.036)

0.003

1.021 (1.005-1.037)

0.009

ECOG state > 1

0.965 (0.712-1.307)

0.817

0.931 (0.618-1.403)

0.733

0.987 (0.617-1.581)

0.958

RPA-class > 4

1.191 (0.898-1.579)

0.225

1.062 (0.731-1.543)

0.751

1.237 (0.789-1.937)

0.354

Incomplete resection

1.498 (1.193-1.881)

0.001

1.126 (0.812-1.560)

0.477

1.889 (1.347-2.647)

<0.001

Simultaneous CT

0.653 (0.488-0.874)

0.004

0.572 (0.398-0.823)

0.003

0.652 (0.381-1.116)

0.119

Fractionation

1.117 (0.865-1.443)

0.396

-

-

-

-

Radiation treatment time

1.010 (0.972-1.049)

0.681

1.008 (0.956-1.064)

0.762

0.997 (0.943-1.055)

0.928

Age

1.021 (1.011-1.032)

<0.001

1.022 (1.008-1.037)

0.003

1.021 (1.005-1.037)

0.009

ECOG state > 1

0.971 (0.791-1.310)

0.846

0.945 (0.631-1.415)

0.785

0.985 (0.619-1.569)

0.950

RPA-class > 4

1.194 (0.901-1.583)

0.218

1.070 (0.736-1.554)

0.749

1.236 (0.790-1.936)

0.354

Incomplete resection

1.510 (1.201-1.899)

<0.001

1.076 (0.779-1.485)

0.435

1.890 (1.350-2.644)

<0.001

Simultaneous CT

0.663 (0.496-0.884)

0.005

0.579 (0.402-0.832)

0.003

0.652 (0.383-1.110)

0.115

Fractionation

1.158 (0.866-1.548)

0.324

-

-

-

-

Overall duration of treatment

1.001 (0.992-1.010)

0.847

1.000 (0.986-1.014)

0.960

1.000 (0.987-1.013)

0.999

Age

1.021 (1.010-1.032)

<0.001

1.022 (1.007-1.036)

0.003

1.021 (1.005-1.037)

0.009

ECOG state > 1

0.969 (0.714-1.314)

0.838

0.934 (0.619-1.411)

0.747

0.986 (0.616-1.581)

0.955

RPA-class > 4

1.191 (0.898-1.579)

0.225

1.062 (0.731-1.542)

0.754

1.236 (0.789-1.937)

0.354

Incomplete resection

1.498 (1.193-1.881)

0.001

1.126 (0.812-1.562)

0.477

1.889 (1.348-2.648)

<0.001

Simultaneous CT

0.652 (0.488-0.871)

0.004

0.570 (0.397-0.819)

0.002

0.652 (0.381-1.116)

0.119

Fractionation

1.123 (0.864-1.458)

0.385

-

-

-

-

  1. The impact of time interval from surgery until initiation of radio- or radiochemotherapy (RCT), radiation treatment time and overall duration of local treatment from surgery to the end of radio- or radiochemotherapy on progression free survival (PFS) is shown
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Radiation Oncology

ISSN: 1748-717X

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