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Table 2 Dosimetric coverage of treatment volumes and OARs by treatment cohort

From: Intensity-Modulated Radiotherapy (IMRT) vs Helical Tomotherapy (HT) in Concurrent Chemoradiotherapy (CRT) for Patients with Anal Canal Carcinoma (ACC): an analysis of dose distribution and toxicities

Parameter

IMRT

HT

P-value*

 

Median (range), Mean

Median (range), Mean

 

PTVprimary

   

HI

0.28 (0.10, 1.09), 0.51

0.14 (0.05, 0.36), 0.18

0.015

UI

1.06 (1.04, 1.52), 1.09

1.03 (1.01, 1.07), 1.03

<0.001

PTVnode

   

HI

0.42 (0.14, 1.25), 0.48

0.55 (0.33, 0.79), 0.54

0.06

UI

1.12 (1.04, 1.52), 1.16

1.17 (1.09, 1.21), 1.16

0.15

Bladder

   

V30

94 (51, 100), 88.8

100 (94, 100), 99

0.009

V40

56.5 (13, 92), 55.5

96 (44, 100), 90.9

<0.001

V50

14 (0.9, 54), 17.5

28 (0.2, 35), 21

0.37

Mean (Gy)

40.9 (32.4, 49.5), 41.3

47 (38.3, 49.2), 46.5

0.002

Median (Gy)

41.6 (30.3, 51.1), 41.5

47.1 (37.1, 49.0), 46.5

0.002

Bone Marrow

   

V10

82.5 (47, 98), 78.6

67 (63, 75), 67.4

0.007

V20

62.5 (22, 88), 60.9

56 (51, 60), 56

0.08

Mean (Gy)

27.6 (12.4, 37.4), 27.2

26.2 (23.1, 28.5), 26.3

0.39

Median (Gy)

29.4 (9.1, 44.3), 28.9

28.3 (21.1, 33.4), 28.3

0.81

Femoral heads

   

V30

68.5 (15, 99), 63.7

91 (76, 100), 90.3

<0.001

V40

14.5 (0, 50), 15.3

47 (27, 67), 50

<0.001

V50

0 (0, 14), 1.2

0 (0, 26), 3.1

0.94

Mean (Gy)

32 (23.5, 41.9), 31.5

38.9 (35.4, 44.1), 39.1

<0.001

Median (Gy)

32.7 (23.6, 40.2), 31.6

39.3 (35.2, 43.2), 39.8

<0.001

Peritoneal Cavity

   

V30

26.5 (0.1, 66), 30.7

46 (6, 76), 44.6

0.01

V40

11 (0.9, 53), 17.2

34 (2, 66), 32.5

0.003

V45

4.5 (0, 44), 9.2

22 (0.5, 57), 23.4

0.002

V50

0.9 (0, 17), 1.7

2 (0, 27), 4.1

0.01

Mean (Gy)

20.2 (4.7, 36.4), 20.4

26.3 (9, 40.6), 25.6

0.04

Median (Gy)

19.7 (2.3, 41.8), 19.3

26 (4.1, 45.7), 25.4

0.09

External Genitalia

   

V20

98.5 (62, 100), 91

73 (48, 98), 73.7

<0.001

V30

64 (19, 99), 65

25 (6, 58), 27.1

<0.001

V40

27 (0, 86), 25.7

5 (0, 48), 9.8

0.02

V50

2 (0, 44), 7.2

0.9 (0, 39), 4.4

0.11

Mean (Gy)

33.6 (21.8, 47.6), 33.6

25.1 (18, 38.9), 26

<0.001

Median (Gy)

33.3 (23.9, 48.9), 33.6

23.4 (18.9, 35.2), 24

<0.001

Skin

   

Mean (Gy)

17 (1.4, 21.3), 16

23.1 (11.2, 26.8), 22

<0.001

Median (Gy)

15.9 (11.9, 19.2), 15.9

20.4 (6, 23.4), 19.1

<0.001

  1. *Mann–Whitney test reported.