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Table 1 Overview of the conventional IMRT and MCO-plan quality scores and the inter-rater reliability

From: Multicriteria optimization enables less experienced planners to efficiently produce high quality treatment plans in head and neck cancer radiotherapy

 

Technique

 

Conventional IMRT

MCO

 

Item

Mean (SD)

Mean (SD)

p- value

ICC agreement (95% CI)

1: Dose hot spots in PTVboost

4.7 (0.5)

4.7 (0.5)

1.00

0.26 (−0.36 – 0.6)

2: Dose hotspots in PTVprophylactic

4.4 (0.9)

4.6 (0.5)

0.15

0.51 (0.28 – 0.79)

3: Dose cold spots in PTVboost

3.9 (0.9)

3.5 (0.9)

0.01

0.57 (0.22 – 0.77)

4: Dose cold spots in PTVprophylactic

4.0 (1.2)

3.9 (1.1)

0.45

0.70 (0.45 – 0.84)

5: Conformity of 95% isodose around PTVboost

3.8 (1.0)

3.5 (0.8)

0.11

0.19 (−0.45 – 0.56)

6: Conformity of 95% isodose around PTVprophylactic

4.0 (1.1)

3.7 (1.1)

0.07

0.61 (0.29 – 0.79)

7: Maximum dose to spinal cord

4.9 (0.5)

5.0 (0.2)

0.28

0.83 (0.70 – 0.91)

8: Parotid gland dose

4.4 (0.7)

4.3 (0.7)

0.62

0.67 (0.40 – 0.82)

9: Dose in unspecified tissue

4.0 (0.8)

3.7 (0.8)

0.07

0.28 (−0.31 – 0.61)

10: General plan quality

3.8 (1.2)

3.6 (1.1)

0.29

0.44 (−0.33 – 0.69)

Total

41.7 (6.4)

40.4 (5.4)

0.15

0.65 (0.57 – 0.71)

  1. The plan quality scores range from 1–5 with 5 the highest score. Abbreviations: IMRT intensity-modulated radiotherapy, MCO multicriteria optimization, PTV planning target volume, SD standard deviation, ICC intra-class correlation coefficient, CI confidence interval. Level of statistically significant differences was set to p < 0.005; Bonferroni correction with α = 0.05/10 questions.