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Table 1 Overview of the conventional IMRT and MCO-plan quality scores and the inter-rater reliability

From: Multicriteria optimization enables less experienced planners to efficiently produce high quality treatment plans in head and neck cancer radiotherapy

  Technique
  Conventional IMRT MCO  
Item Mean (SD) Mean (SD) p- value ICC agreement (95% CI)
1: Dose hot spots in PTVboost 4.7 (0.5) 4.7 (0.5) 1.00 0.26 (−0.36 – 0.6)
2: Dose hotspots in PTVprophylactic 4.4 (0.9) 4.6 (0.5) 0.15 0.51 (0.28 – 0.79)
3: Dose cold spots in PTVboost 3.9 (0.9) 3.5 (0.9) 0.01 0.57 (0.22 – 0.77)
4: Dose cold spots in PTVprophylactic 4.0 (1.2) 3.9 (1.1) 0.45 0.70 (0.45 – 0.84)
5: Conformity of 95% isodose around PTVboost 3.8 (1.0) 3.5 (0.8) 0.11 0.19 (−0.45 – 0.56)
6: Conformity of 95% isodose around PTVprophylactic 4.0 (1.1) 3.7 (1.1) 0.07 0.61 (0.29 – 0.79)
7: Maximum dose to spinal cord 4.9 (0.5) 5.0 (0.2) 0.28 0.83 (0.70 – 0.91)
8: Parotid gland dose 4.4 (0.7) 4.3 (0.7) 0.62 0.67 (0.40 – 0.82)
9: Dose in unspecified tissue 4.0 (0.8) 3.7 (0.8) 0.07 0.28 (−0.31 – 0.61)
10: General plan quality 3.8 (1.2) 3.6 (1.1) 0.29 0.44 (−0.33 – 0.69)
Total 41.7 (6.4) 40.4 (5.4) 0.15 0.65 (0.57 – 0.71)
  1. The plan quality scores range from 1–5 with 5 the highest score. Abbreviations: IMRT intensity-modulated radiotherapy, MCO multicriteria optimization, PTV planning target volume, SD standard deviation, ICC intra-class correlation coefficient, CI confidence interval. Level of statistically significant differences was set to p < 0.005; Bonferroni correction with α = 0.05/10 questions.