Concurrent chemoradiotherapy was associated with a higher severe late toxicity rate in nasopharyngeal carcinoma patients compared with radiotherapy alone: a meta-analysis based on randomized controlled trials

Table 3 Relative risk of severe ototoxicity by concurrent chemotherapy regimen

Study	No. of events/patient size		Relative risk	95% CI	P value
Study	CCRT	RT	Relative risk	95% CI	P value
HC
Lee et al. (2011) [19]	22/42	12/51	2.226	1.256 to 3.947
Lee et al. (2010) [21]	37/172	27/176	1.402	0.895 to 2.198
Overall			*1.672*	*1.174 to 2.382*	*0.026*
Non-HC
Chen et al. (2013) [18]	28/158	18/158	1.556	0.898 to 2.695
Chen et al. (2011) [20]	12/116	8/114	1.474	0.626 to 3.471
Wu et al. (2013) [17]	8/59	11/56	1.085	0.421 to 2.794
Ovarall			*1.433*	*0.946 to 2.171*	*0.095*

CCRT: concurrent chemoradiotherapy; RT: radiotherapy; HC: 3-week high-dose cisplatin; non-HC: non-3-week high-dose cisplatin.

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