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Table 2 Univariate and multivariate analysis for local control and overall survival according to patient and tumor characteristics ( § primary treatment vs progression after pretreatment; &complete remission/stable disease vs progressive disease; *colorectal cancer vs. other; **volume and minimum biologically effective dose as continuous variables; ECOG performance status 0 vs. 1-2; abbreviations: GTV=gross tumor volume, PTV=planning target volume, PS= performance status, HR=hazard ratio, CI=95% confidence interval)

From: Stereotactic radiation therapy for liver metastases: factors affecting local control and survival

Local control     
  Univariate   Multivariate  
  HR (CI) p-value HR (CI) p-value
Indication for SBRT § 0.91 (0.42-1.99) 0.82 0.97 (0.35-2.72) 0.96
Prior CTx 0.66 (0.25-1.79) 0.42 0.33 (0.08-1.30) 0.11
Histology* 1.69 (0.72-3.98) 0.22 1.58 (0.61-4.10) 0.35
GTV Volume** 1.003 (1-1.005) 0.03 1.002 (0.99-1.004) 0.27
BED PTV** 0.95 (0.92-0.99) 0.01 0.98 (0.93-1.03) 0.38
BED GTV** 0.97 (0.96-0.99) <0.001 0.98 (0.96-0.996) 0.015
Overall survival     
  Univariate   Multivariate  
  HR (CI) p-value HR (CI) p-value
ECOG PS 0.71 (0.38-1.34) 0.29 0.92 (0.53-2.25) 0.83
Histology* 0.53 (0.29-0.98) 0.04 0.65 (0.32-1.34) 0.25
Prior CTx 0.58 (0.26-1.33) 0.19 0.70 (0.26-1.87) 0.47
Extrahepatic disease status before SBRT& 2.5 (1.3-4.8) 0.005 1.69 (0.81-3.51) 0.16
GTV Volume** 1.003 (1.001-1.004) <0.001 1.003 (1.001-1.004) 0.002
Local recurrence after SBRT 0.80 (0.42-1.52) 0.5 0.70 (0.34-1.48) 0.35