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Table 4 Association analyses between haplotypes and carotid plaque score in post-RT NPC patients

From: Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma

Genes

D’

r 2

Hap

Freq

P cor

1-β

SS 0.8

PON1

       

rs662-rs705379

0.871

0.294

TC

0.290

0.0158

0.849

117

CT

0.446

0.1881

TT

0.019

0.6840

CC

0.245

0.9740

ADIPOQ

       

rs1501299- rs2241766

1

0.168

GG

0.301

0.9740

0.047

1047

TG

0.418

0.9740

TT

0.281

0.9740

TGFB1

       

rs4803455- rs1800470

0.88

0.628

CG

0.573

0.8766

0.033

1363

AA

0.326

0.8766

AG

0.025

0.8766

CA

0.076

0.9740

rs1800470-rs1800469

1

0.936

AG

0.391

0.8766

0.061

875

GA

0.594

0.8766

AA

0.012

0.9740

rs4803455-rs1800470-rs1800469

0.883

0.648

AAG

0.322

0.8766

0.097

638

CGA

0.573

0.8766

CAG

0.069

0.9740

AGA

0.021

0.9740

  1. Five haplotype windows (HWs) include rs662-rs705379, rs1501299-rs2241766, rs4803455-rs1800470, rs1800470-rs1800469, and rs4803455-rs1800470-rs1800469. Post-RT duration and number of cardiovascular risk factors were adjusted using linear regression in all analyses. Multiple testing was corrected by false discovery rate. Statistical power (1-β) was calculated using the model with smallest observed P value. SS0.8 was the sample size to achieve a statistical power of 0.8 in the corresponding analysis. Hap, haplotype; Freq, frequency; P cor , Corrected P value.
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Radiation Oncology

ISSN: 1748-717X

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