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Table 4 Association analyses between haplotypes and carotid plaque score in post-RT NPC patients

From: Association between genetic polymorphisms and carotid atherosclerosis in patients treated with radiotherapy for nasopharyngeal carcinoma

Genes D’ r 2 Hap Freq P cor 1-β SS 0.8
PON1        
rs662-rs705379 0.871 0.294 TC 0.290 0.0158 0.849 117
CT 0.446 0.1881
TT 0.019 0.6840
CC 0.245 0.9740
ADIPOQ        
rs1501299- rs2241766 1 0.168 GG 0.301 0.9740 0.047 1047
TG 0.418 0.9740
TT 0.281 0.9740
TGFB1        
rs4803455- rs1800470 0.88 0.628 CG 0.573 0.8766 0.033 1363
AA 0.326 0.8766
AG 0.025 0.8766
CA 0.076 0.9740
rs1800470-rs1800469 1 0.936 AG 0.391 0.8766 0.061 875
GA 0.594 0.8766
AA 0.012 0.9740
rs4803455-rs1800470-rs1800469 0.883 0.648 AAG 0.322 0.8766 0.097 638
CGA 0.573 0.8766
CAG 0.069 0.9740
AGA 0.021 0.9740
  1. Five haplotype windows (HWs) include rs662-rs705379, rs1501299-rs2241766, rs4803455-rs1800470, rs1800470-rs1800469, and rs4803455-rs1800470-rs1800469. Post-RT duration and number of cardiovascular risk factors were adjusted using linear regression in all analyses. Multiple testing was corrected by false discovery rate. Statistical power (1-β) was calculated using the model with smallest observed P value. SS0.8 was the sample size to achieve a statistical power of 0.8 in the corresponding analysis. Hap, haplotype; Freq, frequency; P cor , Corrected P value.