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Table 5 Selected series of hypopharygeal and laryngeal cancer patients treated with definitive IMRT

From: Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

Study/Year N Site of primary AJCC Stage Median FU in months (range) PTV-HD dose prescription Margin GTV to PTV-HD LRC OS
Miah 2012 [23]   HC + LC II: 2    23 mm or entire organ + 3 mm   
Grp1: 29 III: 28 51 (12-77) Grp1: 63Gy/28f Grp1: 67%, 2y 72%, 2y
Grp2: 31 IV: 30 36 (04-63) Grp2: 67Gy/28f Grp2: 82%, 2y 74%, 2y
Nguyen 2012 [24] 27 LC III: 17 20 (6-57) 70Gy/35f 5-10 mm n.r. 80%, 2y
IV: 10 62%, 3y
Liu 2010 [22] 27 HC II: 5 36 (2-82) 72.6Gy/35f 5 mm 63%, 5y 35%, 5y
III: 4 76.8Gy/37f
IV: 18
Huang 2010 [25] 33 HC II: 2 25.8 (14.2-72.3) 70Gy/35f 4 mm n.r. 44%, 5y
III: 5
IV: 26
Studer 2010 [26] 123 HC+LC II: 16 26 (3-83) 66Gy/30f 10-15 mm 77%, 2y 83%, 2y
III: 23 69.6/33f
IV: 77 70Gy/35f
Daly 2011 [27] 31 HC+LC II: n.r. 30 (13-98) 66Gy/30f 8-13 mm 80%, 3y 46%, 3y
III: n.r.
IV: n.r.
Mok 2014 [28] 181 HC n.r. IMRT: 50.4 60Gy/25f 5-10 mm IMRT: 75%, 3y IMRT: 50%, 3y
3D-RT: 106.8 62Gy/40f
64Gy/40f 3D-RT: 58%, 3y 3D-RT: 52%, 3y
70Gy/35f
Lee 2007 [29] 31 HC+LC III: 9 24 (17-58) 70Gy/33f 5-10 mm LRPFS 63%, 2y
IV: 21 84%, 2y
Current study 50 HC+LC III: 14 39 (1-79) 70Gy/35f 8-15 mm 80%, 2y 69%, 2y
IV: 36 77%, 3y 63%, 3y
  1. Abbreviations: N number of patients, AJCC American Joint Commission on Cancer, FU Follow-Up, PTV-HD Planning Target Volume High-Dose, GTV Gross Tumor Volume, LRC loco-regional control, OS overall survival, Grp1 Group treated with moderate acceleration, Grp2 Group treated with dose escalation, HC Hypopharyngeal cancer, LC Laryngeal Cancer, n.r. not reported.