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Table 5 Selected series of hypopharygeal and laryngeal cancer patients treated with definitive IMRT

From: Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

Study/Year

N

Site of primary

AJCC Stage

Median FU in months (range)

PTV-HD dose prescription

Margin GTV to PTV-HD

LRC

OS

Miah 2012 [23]

 

HC + LC

II: 2

  

23 mm or entire organ + 3 mm

  

Grp1: 29

III: 28

51 (12-77)

Grp1: 63Gy/28f

Grp1: 67%, 2y

72%, 2y

Grp2: 31

IV: 30

36 (04-63)

Grp2: 67Gy/28f

Grp2: 82%, 2y

74%, 2y

Nguyen 2012 [24]

27

LC

III: 17

20 (6-57)

70Gy/35f

5-10 mm

n.r.

80%, 2y

IV: 10

62%, 3y

Liu 2010 [22]

27

HC

II: 5

36 (2-82)

72.6Gy/35f

5 mm

63%, 5y

35%, 5y

III: 4

76.8Gy/37f

IV: 18

Huang 2010 [25]

33

HC

II: 2

25.8 (14.2-72.3)

70Gy/35f

4 mm

n.r.

44%, 5y

III: 5

IV: 26

Studer 2010 [26]

123

HC+LC

II: 16

26 (3-83)

66Gy/30f

10-15 mm

77%, 2y

83%, 2y

III: 23

69.6/33f

IV: 77

70Gy/35f

Daly 2011 [27]

31

HC+LC

II: n.r.

30 (13-98)

66Gy/30f

8-13 mm

80%, 3y

46%, 3y

III: n.r.

IV: n.r.

Mok 2014 [28]

181

HC

n.r.

IMRT: 50.4

60Gy/25f

5-10 mm

IMRT: 75%, 3y

IMRT: 50%, 3y

3D-RT: 106.8

62Gy/40f

64Gy/40f

3D-RT: 58%, 3y

3D-RT: 52%, 3y

70Gy/35f

Lee 2007 [29]

31

HC+LC

III: 9

24 (17-58)

70Gy/33f

5-10 mm

LRPFS

63%, 2y

IV: 21

84%, 2y

Current study

50

HC+LC

III: 14

39 (1-79)

70Gy/35f

8-15 mm

80%, 2y

69%, 2y

IV: 36

77%, 3y

63%, 3y

  1. Abbreviations: N number of patients, AJCC American Joint Commission on Cancer, FU Follow-Up, PTV-HD Planning Target Volume High-Dose, GTV Gross Tumor Volume, LRC loco-regional control, OS overall survival, Grp1 Group treated with moderate acceleration, Grp2 Group treated with dose escalation, HC Hypopharyngeal cancer, LC Laryngeal Cancer, n.r. not reported.
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Radiation Oncology

ISSN: 1748-717X

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