Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

Table 3 Patterns of recurrence according to CTV coverage

Patient	Primary tumor	Local vs. regional failure	Full coverage by CTV54	Marginal coverage by CTV54	Full coverage by CTV66	Marginal coverage by CTV66	Full coverage by CTV72	Marginal coverage by CTV72	Most probable explanation for relapse
1	larynx	local	Yes	No	Yes	No	Yes	No	radioresistance
2	hypopharynx	local	Yes	No	NA	NA	No	Yes	underdosage
3	hypopharynx	local	Yes	No	Yes	No	Yes	No	radioresistance
4	larynx	local	Yes	No	Yes	No	No	Yes	underdosage
5	larynx	local	Yes	No	NA	NA	Yes	No	radioresistance
6	hypopharynx	regional	Yes	No	No	Yes	No	Yes	underdosage
7	larynx	local	Yes	No	NA	NA	Yes	No	radioresistance
8	larynx	local and regional	Yes	No	NA	NA	Yes	No	radioresistance
9	hypopharynx	local	Yes	No	No	Yes	No	Yes	underdosage
10	hypopharynx	local	Yes	No	Yes	No	Yes	No	radioresistance

Abbreviations: CTV clinical target volume, CTV54 clinical target volume covered by 54Gy, CTV66 clinical target volume covered by 66Gy, CTV72 clinical target volume covered by 72Gy, NA non-applicable.

ISSN: 1748-717X